Search Results

Overview

Uniprot ID	A0A0G2K4T3
Protein Name	Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein
Gene Name	Acap2
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
401	SGSESKEKLLKGESA

Function

GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6). Doesn't show GAP activity for RAB35

Protein Sequence

10 MKMTVDFEEC 20 LKDSPRFRAA 30 LEEVEGDVAE 40 LELKLDKLVK 50 LCIAMIDTGK 60 AFCAANKQFM 70 NGIRDLAQYS 80 SNDAVVETSL 90 TKFSDSLQEM 100 INFHTILFDQ 110 TQRSIKAQLQ 120 NFVKEDLRKF 130 KDAKKQFEKV 140 SEEKENALVK 150 NAQVQRNKQH 160 EVEEAANILT 170 ATRKCFRHIA 180 LDYVLQINVL 190 QSKRRSEILK 200 SMLSFMYAHL 210 AFFHQGYDLF 220 SELGPYMKDL 230 GAQLDRLVVD 240 AAKEKREMEQ 250 KHSTIQQKDF 260 SSDDSKLEYN 270 VDAANGIVME 280 GYLFKRASNA 290 FKTWNRKKPD 300 HIRRWFSIQN 310 NQLVYQKKFK 320 DSPTVVVEDL 330 RLCTVKHCED 340 IERRFCFEVV 350 SPTKSCMLQA 360 DSEKLRQAWI 370 KAVQTSIATA 380 YREKGDESEK 390 LDKKSSPSTG 400 SLDSGSESKE 410 KLLKGESALQ 420 RVQCIPGNTS 430 CCDCGLADPR 440 WASINLGITL 450 CIECSGIHRS 460 LGVHFSKVRS 470 LTLDTWEPEL 480 LKLMCELGND 490 VINRVYEAKL 500 EKMGVKKPQP 510 GQRQEKEAYI 520 RAKYVERKFV 530 DKYSTLLSPS 540 EQEKRIISKS 550 CEDQRLSHTR 560 VSVHTPVKSN 570 DSGIQQCSDD 580 GRESLPSTVS 590 ANSLYEPEGE 600 RQESSVFLDS 610 KHLNPGLQLY 620 RASYEKNLPK 630 MAEALAHGAD 640 VNWANSDENQ 650 ATPLIQAVLG 660 GSLVTCEFLL 670 QNGANVNQRD 680 VQGRGPLHHA 690 TVLGHTGQVC 700 LFLKRGANQH 710 ATDEEGKDPL 720 SIAVEAANAD 730 IVTLLRLARM 740 NEEMRESEGL 750 YGQPGDETYQ 760 DIFRDFSQMA 770 SNNPEKLNRF QQDSQKF

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0010008	endosome membrane
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0005096	GTPase activator activity
Molecular Function	GO:0008270	zinc ion binding

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.