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Overview

Uniprot ID	A0A0G2K4T7
Protein Name	General transcription factor II-I
Gene Name	Gtf2i
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
354	VREFNFEKWNARITD
562	PRTNTPVKEDWNVRI
665	MASKINTKALQSPKR
671	TKALQSPKRPRSPGS

Function

Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation

Protein Sequence

10 MAQVAMSALP 20 AEDEESSESR 30 MVVTFLMSAL 40 ESMCKELAKS 50 KAEVACIAVY 60 ETDVFVVGTE 70 RGRAFVNTRK 80 DFQKDFVKYC 90 VEEEEKAAEM 100 HKMKCTTQAN 110 RMSVDAVEIE 120 TLRKTVEDYF 130 CFCYGKALGK 140 STVVPVPYEK 150 MLRDQSAVAV 160 QGLPEGVAFK 170 HPEHYDLATL 180 KWILENKAGI 190 SFIIKRPFLE 200 PKKHLGGRVM 210 AADADRPMLS 220 PGGSCGPIKV 230 KTEPTEDSGI 240 SLEMAAVTVK 250 EESEDPDYYQ 260 YNIQAGPSET 270 DDVDEKLPLS 280 KALQGSHHSS 290 EGNEGAEVEV 300 PAEDSTQHVP 310 SETSEDPEVE 320 VTIEDDDYSP 330 PTKRPKSSEP 340 PPPPPVPEPT 350 NAGKRKVREF 360 NFEKWNARIT 370 DLRKQVEELF 380 ERKYAQAIKA 390 KGPVTIPYPL 400 FQSHVEDLYV 410 EGLPEGIPFR 420 RPSTYGIPRL 430 ERILLAKERI 440 RFVIKKHELL 450 NSTREDLQLD 460 KPASGVKEEW 470 YARITKLRKM 480 VDQLFCKKFA 490 EALGSTEAKA 500 VPYQKFEAYP 510 NDLYVEGLPE 520 NIPFRSPSWY 530 GIPRLEKIIQ 540 VGNRIKFVIK 550 RPELLTHSTT 560 EVTQPRTNTP 570 VKEDWNVRIT 580 KLRKQVEEIF 590 NLKFAQALGL 600 TEAVKVPYPV 610 FESNPEFLYV 620 EGLPEGIPFR 630 SPTWFGIPRL 640 ERIVRGSNKI 650 KFVVKKPELV 660 VSYLPPGMAS 670 KINTKALQSP 680 KRPRSPGSNS 690 KVPEIEVTVE 700 GPNNNSPQTS 710 TVRTPTQTNG 720 SNVPFKPRGR 730 EFSFEAWNAK 740 ITDLKQKVEN 750 LFNEKCGEAL 760 GLKQAVKVPF 770 ALFESFPEDF 780 YVEGLPEGVP 790 FRRPSTFGIP 800 RLEKILRNKA 810 KIKFIIKKPE 820 MFETAIKEST 830 SSKSPPRKTN 840 SSPSVNTTAS 850 GVEDLNIIQV 860 TIPDDDNERL 870 SKVEKARQLR 880 EQVNDLFSRK 890 FGEAIGMGFP 900 VKVPYRKITI 910 NPGCVVVDGM 920 PPGVSFKAPS 930 YLEISSMRRI 940 LDSAEFIKFT 950 VIRPFPGLVI 960 NNQLVDQNES 970 EGPVIQESAE 980 ASQLEVPATE 990 EIKETDGSSQ IKQEPDPTW

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0003677	DNA binding
Biological Process	GO:0006366	transcription by RNA polymerase II

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.