Search Results

Overview

Uniprot ID	A0A0G2K4X5
Protein Name	Zinc fingers and homeoboxes protein 3
Gene Name	Zhx3
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
183	ITKTPIMKIMKGKAE
723	SPIKINLKNLRVTEA

Function

Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA

Protein Sequence

10 MASKRKSTTP 20 CMIPVKTMVL 30 PGASTEAQPV 40 EPLPEGPQQD 50 LPSEAPEASS 60 EAAPNPSSTD 70 GSALANGHRG 80 TLDGYVYSCK 90 ECDFRSQDVT 100 HFVGHMTSEH 110 TDFNKDPHFV 120 CTGCSFLAKT 130 PEGLSLHNAK 140 CHSGEASFLW 150 NVTKPDNHVV 160 VEQSVPENAS 170 SSVLAGESTE 180 GTEIIITKTP 190 IMKIMKGKAE 200 AKKIHMLKEN 210 APTQPGGEAL 220 PKPLAGETEG 230 KEGDHTFING 240 ATPVSQASAN 250 STKPPHTANG 260 PLIGTVPVLP 270 AGIAQFLSLQ 280 QPTVHPQHHP 290 HQPLPTSKAL 300 PKVMIPLSSI 310 PTYNAAMDSN 320 SFLKNSFHKF 330 PYPTKAELCY 340 LTVVTKYPEE 350 QLKIWFTAQR 360 LKQGISWSPE 370 EIEDARKKMF 380 NTVIQSVPQP 390 TITVLNTPLV 400 ASAGNVQHLI 410 QAALPGHAVG 420 QPEGTAGGLL 430 VTQPLMANGL 440 QASSSSLPLT 450 TASVPKPTAA 460 PINTVCSNTT 470 SAVKVVNAAQ 480 SLLTACPSIT 490 SQAFLDANIY 500 KNKKSHEQLS 510 ALKGSFCRNQ 520 FPGQSEVEHL 530 TKVTGLSTRE 540 VRKWFSDRRY 550 HCRNLKGTRA 560 MVPGEHGSVL 570 IDSVPEVPFP 580 LSSKVPEVPC 590 VPTATSLVSH 600 PATKRQSWHQ 610 TPDFTPTKYK 620 ERAPEQLRVL 630 ESSFAQNPLP 640 PEEELDRLRS 650 ETKMTRREID 660 GWFSERRKRV 670 NAEETKKADG 680 HAPQEEAEGA 690 EEEGRDEELA 700 SELRAPGENG 710 SSEMFLSHTL 720 AERKVSPIKI 730 NLKNLRVTEA 740 SGKSELPGMG 750 MGVCEPEEDG 760 LNKAVEQPPS 770 RVSYKKTAQQ 780 RHLLRQLFVQ 790 TQWPSNQDYD 800 SIMAQTGLPR 810 PEVVRWFGDS 820 RYALKNGQLK 830 WYEDYKRGNF 840 PPGLLVIAPG 850 NRELLQDYYM 860 THKMLCEEDL 870 QTLCEKTQMS 880 AQQVKQWFAE 890 KMGEETRAVA 900 DTSSEDQGPG 910 HGEPVAVDKV 920 LGDACAALSE 930 NSEAWEPSAP 940 EAGSEPFDTS 950 SPQSGRQLGK 960 GLMGSVHGLS 970 RNLRGGYSHR 980 VGTGGRYCYL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005654	nucleoplasm
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0003700	DNA-binding transcription factor activity
Molecular Function	GO:0046982	protein heterodimerization activity
Molecular Function	GO:0042803	protein homodimerization activity
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0030154	cell differentiation
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0045892	negative regulation of DNA-templated transcription
Biological Process	GO:0045669	positive regulation of osteoblast differentiation

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.