Search Results
Overview
| Uniprot ID | A0A0G2K5L2 |
|---|---|
| Protein Name | Mitochondrial glutamate carrier 1 |
| Gene Name | Slc25a22 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 4 | ****MADKQISLPAK |
Function
Mitochondrial glutamate/H(+) symporter (By similarity). Responsible for the transport of glutamate from the cytosol into the mitochondrial matrix with the concomitant import of a proton (Probable). Plays a role in the control of glucose-stimulated insulin secretion (PubMed:19584051)
Protein Sequence
10
MADKQISLPA
20
KLINGGIAGL
30
IGVTCVFPID
40
LAKTRLQNQQ
50
NGQRMYASMS
60
DCLIKTIRSE
70
GYFGMYRGAA
80
VNLTLVTPEK
90
AIKLAANDFF
100
RHQLSKDGQK
110
LTLPKEMLAG
120
CGAGTCQVIV
130
TTPMEMLKIQ
140
LQDAGRIAAQ
150
RKMLAAQAQL
160
ATQGGGQPSV
170
EAPAAPRPTA
180
TQLTRDLLRN
190
HGIAGLYKGL
200
GATLLRDVPF
210
SIVYFPLFAN
220
LNQLGRPSSE
230
EKSPFYVSFL
240
AGCVAGSAAA
250
VAVNPCDVVK
260
TRLQSLERGV
270
NEDTYSGFLD
280
CARKIWRHEG
290
PSAFLKGAYC
300
RALVIAPLFG
310
IAQVVYFLGI
320
AESLLGLLQE
PQA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Molecular Function | GO:0005280 | amino acid:proton symporter activity |
| Molecular Function | GO:0015183 | L-aspartate transmembrane transporter activity |
| Molecular Function | GO:0005313 | L-glutamate transmembrane transporter activity |
| Biological Process | GO:0015810 | aspartate transmembrane transport |
| Biological Process | GO:0015813 | L-glutamate transmembrane transport |
| Biological Process | GO:0043490 | malate-aspartate shuttle |
| Biological Process | GO:0050796 | regulation of insulin secretion |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.