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Overview

Uniprot IDA0A0G2K6U1
Protein NameVesicle-fusing ATPase
Gene NameNsf
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
105 EIDFLQKKNIDSNPY
161 AMDPSILKGEPASGK
198 SSLNLIGKAKTKENR
254 QMGCKHVKGILLYGP
304 ESEANIRKLFADAEE
401 EIGLPDEKGRLQILH
44 VRTSPNHKYIFTLRT
462 RHIKASTKVEVDMEK
469 KVEVDMEKAESLQVT
572 IKICSPDKMIGFSET
581 IGFSETAKCQAMKKI
587 AKCQAMKKIFDDAYK
639 KAPPQGRKLLIIGTT
699 TTIAQQVKGKKVWIG
702 AQQVKGKKVWIGIKK
728 DPEYRVRKFLALMRE

Function

Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin

Protein Sequence

10 VAGLTMQAAR 20 CPTDELSLSN 30 CAVVNEKDYQ 40 SGQHVMVRTS 50 PNHKYIFTLR 60 THPSVVPGCI 70 AFSLPQRKWA 80 GLSIGQDIEV 90 ALYSFDKAKQ 100 CIGTMTIEID 110 FLQKKNIDSN 120 PYDTDKMAAE 130 FIQQFNNQAF 140 SVGQQLVFSF 150 NDKLFGLLVK 160 DIEAMDPSIL 170 KGEPASGKRQ 180 KIEVGLVVGN 190 SQVAFEKAEN 200 SSLNLIGKAK 210 TKENRQSIIN 220 PDWNFEKMGI 230 GGLDKEFSDI 240 FRRAFASRVF 250 PPEIVEQMGC 260 KHVKGILLYG 270 PPGCGKTLLA 280 RQIGKMLNAR 290 EPKVVNGPEI 300 LNKYVGESEA 310 NIRKLFADAE 320 EEQRRLGANS 330 GLHIIIFDEI 340 DAICKQRGSM 350 AGSTGVHDTV 360 VNQLLSKIDG 370 VEQLNNILVI 380 GMTNRPDLID 390 EALLRPGRLE 400 VKMEIGLPDE 410 KGRLQILHIH 420 TARMRGHQLL 430 SADVDIKELA 440 VETKNFSGAE 450 LEGLVRAAQS 460 TAMNRHIKAS 470 TKVEVDMEKA 480 ESLQVTRGDF 490 LASLENDIKP 500 AFGTNQEDYA 510 SYIMNGIIKW 520 GDPVTRVLDD 530 GELLVQQTKN 540 SDRTPLVSVL 550 LEGPPHSGKT 560 ALAAKIAEES 570 NFPFIKICSP 580 DKMIGFSETA 590 KCQAMKKIFD 600 DAYKSQLSCV 610 VVDDIERLLD 620 YVPIGPRFSN 630 LVLQALLVLL 640 KKAPPQGRKL 650 LIIGTTSRKD 660 VLQEMEMLNA 670 FSTTIHVPNI 680 ATGEQLLEAL 690 ELLGNFKDKE 700 RTTIAQQVKG 710 KKVWIGIKKL 720 LMLIEMSLQM 730 DPEYRVRKFL 740 ALMREEGASP LDFD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0046872 metal ion binding
Biological Process GO:0015031 protein transport
Biological Process GO:0035494 SNARE complex disassembly

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.