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Overview

Uniprot ID	A0A0G2K7B3
Protein Name	-
Gene Name	Hnrnpc
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
144	ARAVVPSKRQRVSGN
163	GKSGFNSKSGQRGSS
211	KIEKEQSKQAVEMKN
8	MASNVTNKTDPRSMN

Function

Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing

Protein Sequence

10 MASNVTNKTD 20 PRSMNSRVFI 30 GNLNTLVVKK 40 SDVEAIFSKY 50 GKIVGCSVHK 60 GFAFVQYVNE 70 RNARAAVAGE 80 DGRMIAGQVL 90 DINLAAEPKV 100 NRGKAGVKRS 110 AAEMYGSSFD 120 LDYDFQRDYY 130 DRMYSYPARV 140 PPPPPIARAV 150 VPSKRQRVSG 160 NTSRRGKSGF 170 NSKSGQRGSS 180 SKSGKLKGDD 190 LQAIKKELTQ 200 IKQKVDSLLE 210 SLEKIEKEQS 220 KQAVEMKNEK 230 SEEEQSSASV 240 KKDETNVKME 250 SEAGADDSAE 260 EGDLLDDDDN 270 EDRGDDQLEL 280 KDDEKEPEEG 290 EDDRDSANGE DDS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:1990904	ribonucleoprotein complex
Molecular Function	GO:0003723	RNA binding

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.