Search Results

Overview

Uniprot ID	A0A0G2K7T2
Protein Name	Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
Gene Name	Gne
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
226	KLLSAKNKDYMSIIR

Function

No function data available.

Protein Sequence

10 METHMPLHRE 20 QSHAGPHELY 30 FKKLSSKKKQ 40 VMEKNGNNRK 50 LRVCVATCNR 60 ADYSKLAPIM 70 FGIKTEPAFF 80 ELDVVVLGSH 90 LIDDYGNTYR 100 MIEQDDFDIN 110 TRLHTIVRGE 120 DEAAMVESVG 130 LALVKLPDVL 140 NRLKPDIMIV 150 HGDRFDALAL 160 ATSAALMNIR 170 ILHIEGGEVS 180 GTIDDSIRHA 190 ITKLAHYHVC 200 CTRSAEQHLI 210 SMCEDHDRIL 220 LAGCPSYDKL 230 LSAKNKDYMS 240 IIRMWLGDDV 250 KCKDYIVALQ 260 HPVTTDIKHS 270 IKMFELTLDA 280 LISFNKRTLV 290 LFPNIDAGSK 300 EMVRVMRKKG 310 IEHHPNFRAV 320 KHVPFDQFIQ 330 LVAHAGCMIG 340 NSSCGVREVG 350 AFGTPVINLG 360 TRQIGRETGE 370 NVLHVRDADT 380 QDKILQALHL 390 QFGKQYPCSK 400 IYGDGNAVPR 410 ILKFLKSIDL 420 QEPLQKKFCF 430 PPVKENISQD 440 IDHILETLSA 450 LAVDLGGTNL 460 RVAIVSMKGE 470 IVKKYTQFNP 480 KTYEERISLI 490 LQMCVEAAAE 500 AVKLNCRILG 510 VGISTGGRVN 520 PQEGVVLHST 530 KLIQEWNSVD 540 LRTPLSDTLH 550 LPVWVDNDGN 560 CAAMAERKFG 570 QGKGQENFVT 580 LITGTGIGGG 590 IIHQHELIHG 600 SSFCAAELGH 610 LVVSLDGPDC 620 SCGSHGCIEA 630 YASGMALQRE 640 AKKLHDEDLL 650 LVEGMSVPKD 660 EAVGALHLIQ 670 AAKLGNVKAQ 680 SILRTAGTAL 690 GLGVVNILHT 700 MNPSLVILSG 710 VLASHYIHIV 720 RDVIRQQALS 730 SVQDVDVVVS 740 DLVDPALLGA 750 ASMVLDYTTR RIH

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0009384	N-acylmannosamine kinase activity
Molecular Function	GO:0008761	UDP-N-acetylglucosamine 2-epimerase activity
Biological Process	GO:0006055	CMP-N-acetylneuraminate biosynthetic process
Biological Process	GO:0046380	N-acetylneuraminate biosynthetic process
Biological Process	GO:0006047	UDP-N-acetylglucosamine metabolic process

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.