Overview
| Uniprot ID | A0A0G2K866 |
|---|
| Protein Name | Iron-sulfur clusters transporter ABCB7, mitochondrial |
|---|
| Gene Name | Abcb7 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 753 |
AKKESLSKEEERKKL |
Function
Exports glutathione-coordinated iron-sulfur clusters such as [2Fe-2S]-(GS)4 cluster from the mitochondria to the cytosol in an ATP-dependent manner allowing the assembly of the cytosolic iron-sulfur (Fe/S) cluster-containing proteins and participates in iron homeostasis. Moreover, through a functional complex formed of ABCB7, FECH and ABCB10, also plays a role in the cellular iron homeostasis, mitochondrial function and heme biosynthesis. In cardiomyocytes, regulates cellular iron homeostasis and cellular reactive oxygen species (ROS) levels through its interaction with COX4I1. May also play a role in hematopoiesis
Protein Sequence
10
MKAAALSPPA
20
SHNPPLSVPF
30
PSLKMALLAI
40
HSWRWAAAAV
50
AFEKHKHSAV
60
LTRSLVSICG
70
SGLRWSSYQS
80
GASGSARLSQ
90
TTESLRNSTQ
100
QRWEKNNSRQ
110
LLDASKVLQA
120
WPLIEKRTCW
130
HGHAGGGLHT
140
DPKEGLKDVD
150
TRKIIKAMLS
160
YVWPKDRPDL
170
RARVAISLGF
180
LGGAKAMNIV
190
VPFMFKYAVD
200
SLNQMSGNML
210
NLSDAPNTVA
220
TMATAVLIGY
230
GVSRAGAAFF
240
NEVRNAVFGK
250
VAQNSIRRIA
260
KNVFLHLHNL
270
DLGFHLSRQT
280
GALSKAIDRG
290
TRGISFVLSA
300
LVFNLLPIVF
310
EMTLVSSVLY
320
YKCGAQFALV
330
TLGTLGAYTA
340
FTVAVTRWRT
350
RFRIEMNKAD
360
NDAGNAAIDS
370
LLNYETVKYF
380
NNEKYEAQRY
390
DGFLKTYETA
400
SLKSTSTLAM
410
LNFGQSAIFS
420
VGLTAIMVLA
430
SQGIVAGALT
440
VGDLVMVNGL
450
LFQLSLPLNF
460
LGTVYRETRQ
470
ALIDMNTLFT
480
LLKVDTRIKD
490
KAMASPLQIT
500
PQTATVAFDN
510
VHFEYIEGQK
520
VLSGVSFEVP
530
AGKKVAIVGG
540
SGSGKSTIVR
550
LLFRFYEPQK
560
GSIYLAGQNI
570
QDVSLESLRR
580
AVGVVPQDAV
590
LFHNTIYYNL
600
LYGNINASPE
610
EVYAVAKLAG
620
LHDAILRMPH
630
GYDTQVGERG
640
LKLSGGEKQR
650
VAIARAILKD
660
PPVILYDEAT
670
SSLDSITEET
680
ILGAMRDVVK
690
HRTSIFIAHR
700
LSTVVDADEI
710
IVLSQGKVAE
720
RGTHYGLLAN
730
SSSIYSEMWH
740
TQSTRIQNHD
750
NLGWDAKKES
760
LSKEEERKKL
770
QEEIVNSVKG
CGNCSC
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Molecular Function |
GO:0140481 |
ABC-type iron-sulfur cluster transporter activity |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0016887 |
ATP hydrolysis activity |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Biological Process |
GO:0006879 |
intracellular iron ion homeostasis |
| Biological Process |
GO:0016226 |
iron-sulfur cluster assembly |
| Biological Process |
GO:0140466 |
iron-sulfur cluster export from the mitochondrion |
| Biological Process |
GO:0070455 |
positive regulation of heme biosynthetic process |
| Biological Process |
GO:1903331 |
positive regulation of iron-sulfur cluster assembly |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.