Search Results

Overview

Uniprot IDA0A0G2K867
Protein NameOtoferlin
Gene NameOtof
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
1530 GKTDIRDKENYISKQ

Function

Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses. Interacts in a calcium-dependent manner to the presynaptic SNARE proteins at ribbon synapses of cochlear inner hair cells (IHCs) to trigger exocytosis of neurotransmitter. Also essential to synaptic exocytosis in immature outer hair cells (OHCs). May also play a role within the recycling of endosomes

Protein Sequence

10 MALIVHLKTV 20 SELRGRADRI 30 AKVTFRGQSF 40 YSRVLENCED 50 VADFDETFRW 60 PVASSIDRNE 70 VLEIQIFNYS 80 KVFSNKLIGT 90 FRMVLQKVVE 100 ENRVEVSDTL 110 IDDNNAIIKT 120 SLSMEVRYQA 130 ADGTVGPWDD 140 GDFLGDESLQ 150 EEEKDSQETD 160 GLLPGSRPST 170 RTPGEKSFRR 180 AGRSVFSAMK 190 LGKTRSHKEE 200 PQRQDEPAVL 210 EMEDLDHLAI 220 RLGDGLDPDS 230 VSLASVTALT 240 SNVSNKRSKP 250 DIKMEPSAGR 260 PMDYQVSITV 270 IEARQLVGLN 280 MDPVVCVEVG 290 DDKKYTSMKE 300 STNCPYYNEY 310 FVFDFHVSPD 320 VMFDKIIKIS 330 VIHSKNLLRS 340 GTLVGSFKMD 350 VGTVYSQPEH 360 QFHHKWAILS 370 DPDDISAGLK 380 GYVKCDVAVV 390 GKGDNIKTPH 400 KANETDEDDI 410 EGNLLLPEGV 420 PPERQWARFY 430 VKIYRAEGLP 440 RMNTSLMANV 450 KKAFIGENKD 460 LVDPYVQVFF 470 AGQKGKTSVQ 480 KSSYEPLWNE 490 QVVFTDLFPP 500 LCKRMKVQIR 510 DSDKVNDVAI 520 GTHFIDLRKI 530 SNDGDKGFLP 540 TLGPAWVNMY 550 GSTRNYTLLD 560 EHQDLNEGLG 570 EGVSFRARLM 580 LGLAVEILDT 590 SNPELTSSTE 600 VQVEQATPVS 610 ESCTGRMEEF 620 FLFGAFLEAS 630 MIDRKNGDKP 640 VTFEVTIGNY 650 GNEVDGTSRP 660 QRPRPRKEPG 670 DEEEVDLIQN 680 SSDDEGDEAG 690 DLASVSSTPP 700 MRPQITDRNY 710 FHLPYLERKP 720 CIYIKSWWPD 730 QRRRLYNANI 740 MDHIADKLEE 750 GLNDVQEMIK 760 TEKSYPERRL 770 RGVLEELSCG 780 CHRFLSLSDK 790 DQGHSSRTRL 800 DRERLKSCMR 810 ELESMGQQAK 820 SLRAQVKRHT 830 VRDKLRLCQN 840 FLQKLRFLAD 850 EPQHSIPDVF 860 IWMMSNNKRI 870 AYARVPSKDL 880 LFSIVEEELG 890 KDCAKVKTLF 900 LKLPGKRGFG 910 SAGWTVQAKL 920 ELYLWLGLSK 930 QRKDFLCGLP 940 CGFEEVKAAQ 950 GLGLHSFPPI 960 SLVYTKKQTF 970 QLRAHMYQAR 980 SLFAADSTGL 990 SDPFARVFFI 1000 NQSQCTEVLN 1010 ETLCPTWDQM 1020 LVFDNLELYG 1030 EAHELRDDPP 1040 IIVIEIYDQD 1050 SMGKADFMGR 1060 TFAKPLVKMA 1070 DEAYCPPRFP 1080 PQLEYYQIYR 1090 GNATAGDLLA 1100 AFELLQIGPS 1110 GKADLPPING 1120 PVDMDRGPIM 1130 PVPVGIRPVL 1140 SKYRVEVLFW 1150 GLRDLKRVNL 1160 AQVDRPRVDI 1170 ECAGKGVQSS 1180 LIHNYKKNPN 1190 FNTLVKWFEV 1200 DLPENELLHP 1210 PLNIRVVDCR 1220 AFGRYTLVGS 1230 HAVSSLRRFI 1240 YRPPDRSAAN 1250 WNTTVRLLRG 1260 YHMLCNGGPS 1270 SCPTGEVVVS 1280 MEPEVPVKKL 1290 ETLVKLDATS 1300 DAVVKVDVAE 1310 DEKERKKKKK 1320 KGPSEEAEEE 1330 EPDESMLDWW 1340 SKYFASIDTM 1350 KEQLRQHETS 1360 GIDLEEKEEM 1370 DSTEGLKGPV 1380 KNKEKSRAAK 1390 EEKKKKNQNP 1400 GPGQGSEAPE 1410 KKKAKIDELK 1420 VYPKELESEF 1430 DNFEDWLHTF 1440 NLLRGKTGDD 1450 EDGSTEEERI 1460 VGRFKGSLCV 1470 YKVPLPEDVS 1480 REAGYDPTYG 1490 MFQGIPSNDP 1500 INVLVRIYVV 1510 RATDLHPADI 1520 NGKADPYIAI 1530 KLGKTDIRDK 1540 ENYISKQLNP 1550 VFGKSFDIEA 1560 SFPMESMLTV 1570 AVYDWDLVGT 1580 DDLIGETKID 1590 LENRFYSKHR 1600 ATCGIAQTYS 1610 IHGYNIWRDP 1620 MKPSQILTRL 1630 CKEGKVDGPH 1640 FGPHGRVKVA 1650 NRVFTGPSEI 1660 EDENGQRKPT 1670 DEHVALSALR 1680 HWEDIPRVGC 1690 RLVPEHVETR 1700 PLLNPDKPGI 1710 EQGRLELWVD 1720 MFPMDMPAPG 1730 TPLDISPRKP 1740 KKYELRVIVW 1750 NTDEVVLEDD 1760 DFFTGEKSSD 1770 IFVRGWLKGQ 1780 QEDKQDTDVH 1790 YHSLTGEGNF 1800 NWRYLFPFDY 1810 LAAEEKIVMS 1820 KKESMFSWDE 1830 TEYKIPARLT 1840 LQIWDADHFS 1850 ADDFLGAIEL 1860 DLNRFPRGAK 1870 TAKQCTMEMA 1880 TGEVDVPLVS 1890 IFKQKRVKGW 1900 WPLLARNEND 1910 EFELTGKVEA 1920 ELHLLTAEEA 1930 EKNPVGLARN 1940 EPDPLEKPNR 1950 PDTSFIWFLN 1960 PLKSARYFLW 1970 HTYRWLLLKL 1980 LLLLLLLLLL 1990 ALFLYSLPGY LAKKILGA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016323 basolateral plasma membrane
Cellular Component GO:0030672 synaptic vesicle membrane
Molecular Function GO:0046872 metal ion binding
Biological Process GO:0007605 sensory perception of sound
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0000139 Golgi membrane
Cellular Component GO:0042734 presynaptic membrane

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.