Search Results
Overview
| Uniprot ID | A0A0G2K867 |
|---|---|
| Protein Name | Otoferlin |
| Gene Name | Otof |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1530 | GKTDIRDKENYISKQ |
Function
Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses. Interacts in a calcium-dependent manner to the presynaptic SNARE proteins at ribbon synapses of cochlear inner hair cells (IHCs) to trigger exocytosis of neurotransmitter. Also essential to synaptic exocytosis in immature outer hair cells (OHCs). May also play a role within the recycling of endosomes
Protein Sequence
10
MALIVHLKTV
20
SELRGRADRI
30
AKVTFRGQSF
40
YSRVLENCED
50
VADFDETFRW
60
PVASSIDRNE
70
VLEIQIFNYS
80
KVFSNKLIGT
90
FRMVLQKVVE
100
ENRVEVSDTL
110
IDDNNAIIKT
120
SLSMEVRYQA
130
ADGTVGPWDD
140
GDFLGDESLQ
150
EEEKDSQETD
160
GLLPGSRPST
170
RTPGEKSFRR
180
AGRSVFSAMK
190
LGKTRSHKEE
200
PQRQDEPAVL
210
EMEDLDHLAI
220
RLGDGLDPDS
230
VSLASVTALT
240
SNVSNKRSKP
250
DIKMEPSAGR
260
PMDYQVSITV
270
IEARQLVGLN
280
MDPVVCVEVG
290
DDKKYTSMKE
300
STNCPYYNEY
310
FVFDFHVSPD
320
VMFDKIIKIS
330
VIHSKNLLRS
340
GTLVGSFKMD
350
VGTVYSQPEH
360
QFHHKWAILS
370
DPDDISAGLK
380
GYVKCDVAVV
390
GKGDNIKTPH
400
KANETDEDDI
410
EGNLLLPEGV
420
PPERQWARFY
430
VKIYRAEGLP
440
RMNTSLMANV
450
KKAFIGENKD
460
LVDPYVQVFF
470
AGQKGKTSVQ
480
KSSYEPLWNE
490
QVVFTDLFPP
500
LCKRMKVQIR
510
DSDKVNDVAI
520
GTHFIDLRKI
530
SNDGDKGFLP
540
TLGPAWVNMY
550
GSTRNYTLLD
560
EHQDLNEGLG
570
EGVSFRARLM
580
LGLAVEILDT
590
SNPELTSSTE
600
VQVEQATPVS
610
ESCTGRMEEF
620
FLFGAFLEAS
630
MIDRKNGDKP
640
VTFEVTIGNY
650
GNEVDGTSRP
660
QRPRPRKEPG
670
DEEEVDLIQN
680
SSDDEGDEAG
690
DLASVSSTPP
700
MRPQITDRNY
710
FHLPYLERKP
720
CIYIKSWWPD
730
QRRRLYNANI
740
MDHIADKLEE
750
GLNDVQEMIK
760
TEKSYPERRL
770
RGVLEELSCG
780
CHRFLSLSDK
790
DQGHSSRTRL
800
DRERLKSCMR
810
ELESMGQQAK
820
SLRAQVKRHT
830
VRDKLRLCQN
840
FLQKLRFLAD
850
EPQHSIPDVF
860
IWMMSNNKRI
870
AYARVPSKDL
880
LFSIVEEELG
890
KDCAKVKTLF
900
LKLPGKRGFG
910
SAGWTVQAKL
920
ELYLWLGLSK
930
QRKDFLCGLP
940
CGFEEVKAAQ
950
GLGLHSFPPI
960
SLVYTKKQTF
970
QLRAHMYQAR
980
SLFAADSTGL
990
SDPFARVFFI
1000
NQSQCTEVLN
1010
ETLCPTWDQM
1020
LVFDNLELYG
1030
EAHELRDDPP
1040
IIVIEIYDQD
1050
SMGKADFMGR
1060
TFAKPLVKMA
1070
DEAYCPPRFP
1080
PQLEYYQIYR
1090
GNATAGDLLA
1100
AFELLQIGPS
1110
GKADLPPING
1120
PVDMDRGPIM
1130
PVPVGIRPVL
1140
SKYRVEVLFW
1150
GLRDLKRVNL
1160
AQVDRPRVDI
1170
ECAGKGVQSS
1180
LIHNYKKNPN
1190
FNTLVKWFEV
1200
DLPENELLHP
1210
PLNIRVVDCR
1220
AFGRYTLVGS
1230
HAVSSLRRFI
1240
YRPPDRSAAN
1250
WNTTVRLLRG
1260
YHMLCNGGPS
1270
SCPTGEVVVS
1280
MEPEVPVKKL
1290
ETLVKLDATS
1300
DAVVKVDVAE
1310
DEKERKKKKK
1320
KGPSEEAEEE
1330
EPDESMLDWW
1340
SKYFASIDTM
1350
KEQLRQHETS
1360
GIDLEEKEEM
1370
DSTEGLKGPV
1380
KNKEKSRAAK
1390
EEKKKKNQNP
1400
GPGQGSEAPE
1410
KKKAKIDELK
1420
VYPKELESEF
1430
DNFEDWLHTF
1440
NLLRGKTGDD
1450
EDGSTEEERI
1460
VGRFKGSLCV
1470
YKVPLPEDVS
1480
REAGYDPTYG
1490
MFQGIPSNDP
1500
INVLVRIYVV
1510
RATDLHPADI
1520
NGKADPYIAI
1530
KLGKTDIRDK
1540
ENYISKQLNP
1550
VFGKSFDIEA
1560
SFPMESMLTV
1570
AVYDWDLVGT
1580
DDLIGETKID
1590
LENRFYSKHR
1600
ATCGIAQTYS
1610
IHGYNIWRDP
1620
MKPSQILTRL
1630
CKEGKVDGPH
1640
FGPHGRVKVA
1650
NRVFTGPSEI
1660
EDENGQRKPT
1670
DEHVALSALR
1680
HWEDIPRVGC
1690
RLVPEHVETR
1700
PLLNPDKPGI
1710
EQGRLELWVD
1720
MFPMDMPAPG
1730
TPLDISPRKP
1740
KKYELRVIVW
1750
NTDEVVLEDD
1760
DFFTGEKSSD
1770
IFVRGWLKGQ
1780
QEDKQDTDVH
1790
YHSLTGEGNF
1800
NWRYLFPFDY
1810
LAAEEKIVMS
1820
KKESMFSWDE
1830
TEYKIPARLT
1840
LQIWDADHFS
1850
ADDFLGAIEL
1860
DLNRFPRGAK
1870
TAKQCTMEMA
1880
TGEVDVPLVS
1890
IFKQKRVKGW
1900
WPLLARNEND
1910
EFELTGKVEA
1920
ELHLLTAEEA
1930
EKNPVGLARN
1940
EPDPLEKPNR
1950
PDTSFIWFLN
1960
PLKSARYFLW
1970
HTYRWLLLKL
1980
LLLLLLLLLL
1990
ALFLYSLPGY
LAKKILGA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0030672 | synaptic vesicle membrane |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0007605 | sensory perception of sound |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0042734 | presynaptic membrane |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.