Search Results

Overview

Uniprot IDA0A0G2K8T6
Protein NameZinc finger E-box-binding homeobox 2
Gene NameZeb2
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
227 YKRLTSLKEHIKYRH
332 YSSHISSKKCIGLIS
485 CKTEDISKLKGYHMK
555 RRQISNIKKEKLRTL
762 DPPLRLTKSSHFTNI
770 SSHFTNIKAVDKLDH
828 PKQMREPKSIIATKN
993 LSRKKIKKTESGMYA

Function

Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin. Represses expression of MEOX2

Protein Sequence

10 MKQPIMADGP 20 RCKRRKQANP 30 RRKNVVNYDN 40 VVDAGSETDE 50 EDKLHIAEDD 60 GIANPLDQET 70 SPASMPNHES 80 SPHMSQGLLP 90 REEEEDEIRE 100 SVVEHSWHSG 110 EILQASVDGP 120 EEMKEDYDAL 130 GPEATIQTTI 140 NNGTVKNANC 150 TSDFEEYFAK 160 RKLEERDGHA 170 VSIEEYLQRS 180 DTAIIYPEAP 190 EELSRLGTPE 200 ANGQEENDLP 210 PGTPDAFAQL 220 LTCPYCDRGY 230 KRLTSLKEHI 240 KYRHEKNEEN 250 FSCPLCSYTF 260 AYRTQLERHM 270 VTHKPGTDQH 280 QMLTQGAGNR 290 KFKCTECGKA 300 FKYKHHLKEH 310 LRIHSGEKPY 320 ECPNCKKRFS 330 HSGSYSSHIS 340 SKKCIGLISV 350 NGRMRNNIKT 360 GSSPNSVSSS 370 PTNSAITQLR 380 NKLENGKPLS 390 MSEQTGLLKI 400 KTEPLDFNDY 410 KVLMATHGFS 420 GTSPFMNGGL 430 GATSPLGVHP 440 SAQSPMQHLG 450 VGLEAPLLGF 460 PTMNSNLSEV 470 QKVLQIVDNT 480 VSRQKMDCKT 490 EDISKLKGYH 500 MKDPCSQPEE 510 QGVTSPSIPA 520 VGLPVVSHNG 530 ATKSIIDYTL 540 EKVNEAKACL 550 QSLTTDSRRQ 560 ISNIKKEKLR 570 TLIDLVTDDK 580 MIENHSIPTP 590 FSCQFCKESF 600 PGPIPLHQHE 610 RYLCKMNEEI 620 KAVLQPHENI 630 VPNKAGVFVD 640 NKALLLSSVL 650 SEKGLTSPIN 660 PYKDHMSVLK 670 AYYAMNMEPN 680 SDELLKISIA 690 VGLPQEFVKE 700 WFEQRKVYQY 710 SSSRSPSLER 720 NSKPLAPNSN 730 PTTKDSLLPR 740 SPVKPMDSIT 750 SPSIAELHNS 760 VTSCDPPLRL 770 TKSSHFTNIK 780 AVDKLDHSRS 790 NTPSPLNLSS 800 TSSKNSHSSS 810 YTPNSFSSEE 820 LQAEPLDLSL 830 PKQMREPKSI 840 IATKNKTKAT 850 SISLDHNSVS 860 SSSENSDEPL 870 NLTFIKKEFS 880 NSNNLDNKST 890 NPVFGMNPFS 900 AKPLYTALPP 910 QSAFPPATFM 920 PPVQTSIPGL 930 RPYPGLDQMS 940 FLPHMAYTYP 950 TGAATFADMQ 960 QRRKYQRKQG 970 FQGELLDGAQ 980 DYMSGLDDLT 990 DSDSCLSRKK 1000 IKKTESGMYA 1010 CDLCDKTFQK 1020 SSSLLRHKYE 1030 HTATIGTPLK ASFPL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005694 chromosome
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0048023 positive regulation of melanin biosynthetic process
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0030177 positive regulation of Wnt signaling pathway

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.