Search Results
Overview
| Uniprot ID | A0A0G2K911 |
|---|---|
| Protein Name | NSFL1 cofactor p47 |
| Gene Name | Nsfl1c |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 129 | DDLFKGAKEHGAVAV |
| 253 | VKPKGAFKAFTGEGQ |
Function
Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis
Protein Sequence
10
MAEERQDALR
20
EFVAVTGAEE
30
DRARFFLESA
40
GWDLQIALAS
50
FYEDGGDEDI
60
VTISQATPSS
70
VSRGTAPSDN
80
RVTSFRDLIH
90
DQDEEEEEEE
100
GQRSRFYAGG
110
SERSGQQIVG
120
PPRKKSPNEL
130
VDDLFKGAKE
140
HGAVAVERVT
150
KSPGETSKPR
160
PFAGGGYRLG
170
AAPEEESAYV
180
AGERRRHSGQ
190
DVHVVLKLWK
200
TGFSLDNGDL
210
RSYQDPSNAQ
220
FLESIRRGEV
230
PAELRRLAHG
240
GQVNLDMEDH
250
RDEDFVKPKG
260
AFKAFTGEGQ
270
KLGSTAPQVL
280
NTSSPAQQAE
290
NEAKASSSIL
300
INEAEPTTNI
310
QIRLADGGRL
320
VQKFNHSHRI
330
SDIRLFIVDA
340
RPAMAATSFV
350
LMTTFPNKEL
360
ADENQTLKEA
370
NLLNAVIVQR
LT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005795 | Golgi stack |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:1990730 | VCP-NSFL1C complex |
| Molecular Function | GO:0008289 | lipid binding |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.