Overview
| Uniprot ID | A0A0G2K954 |
|---|
| Protein Name | - |
|---|
| Gene Name | Nabp2 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 65 |
TGRVTKTKDGHEVRT |
Function
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways
Protein Sequence
10
MGRPSGSMGQ
20
RLQALNLHLP
30
FPLPAGCHGS
40
GSMTTETFVK
50
DIKPGLKNLN
60
LIFIVLETGR
70
VTKTKDGHEV
80
RTCKVADKTG
90
SINISVWDDV
100
GNLIQPGDII
110
RLTKGGQVRV
120
YKDAMQPAAC
130
VSWLDLSVAR
140
WMSPRLSLLC
150
RFCMVYSEVP
160
NFSEPNPEYN
170
TQQASNKSVQ
180
NDSSPTAPQA
190
TTGPPAASPA
200
SESQNGNGLS
210
TQPGPVGGPH
220
PSHAPSHPPS
230
TRITRSQPNH
240
TPSGPPGPSS
250
SPVSNGKETR
RSSKR
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000781 |
chromosome, telomeric region |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0035861 |
site of double-strand break |
| Cellular Component |
GO:0070876 |
SOSS complex |
| Molecular Function |
GO:0070182 |
DNA polymerase binding |
| Molecular Function |
GO:0098505 |
G-rich strand telomeric DNA binding |
| Biological Process |
GO:0000724 |
double-strand break repair via homologous recombination |
| Biological Process |
GO:0070200 |
establishment of protein localization to telomere |
| Biological Process |
GO:0044818 |
mitotic G2/M transition checkpoint |
| Biological Process |
GO:1904355 |
positive regulation of telomere capping |
| Biological Process |
GO:0010212 |
response to ionizing radiation |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.