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Overview

Uniprot ID	A0A0G2K9A7
Protein Name	WD repeat-containing protein 75
Gene Name	Wdr75
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
196	NFTLPSTKNKKNARN

Function

Ribosome biogenesis factor. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I

Protein Sequence

10 MVEERVRVVR 20 CGGSRLNFRR 30 AVFSVDSKYI 40 FCVSGDFIKV 50 YSTATEECVH 60 ILRGHKHVVS 70 GILINPNNHL 80 QLYSCSFDGT 90 IKLWDYLDGI 100 LIKTFTVGPK 110 LHALFIPAHA 120 EDTVFLTINK 130 EDPDIFQLVS 140 VKLPKSTSRN 150 VEAKELTFVL 160 DYINKSPKSI 170 AFGNEGEYVA 180 AVRDFYLSVY 190 FLKKKKTCNF 200 TLPSTKNKKN 210 ARNKFTCVAC 220 HPKEDCIASG 230 HMDGKIRLWR 240 NFHDDKLYTY 250 TCLHWHHDMV 260 MDLAFTVTGT 270 SLLSGGQECV 280 LVEWRDGSEK 290 NKEFLPRLGS 300 AIEHISVSPA 310 GDLFCTSHSD 320 NKITVIHRNL 330 DASAVIQGLV 340 KDRSISTGLM 350 VDPRTKALVL 360 NGKPGHLQFY 370 SLQSDKQLYN 380 LDIIQQEYIN 390 DQGLIQIELT 400 KAAFGCSGSW 410 LATVEQRQEN 420 ENELELQMKL 430 WNYSKKTQGF 440 VLNTKISMPH 450 DDHITALCFN 460 NAENYEKPIL 470 VTASRDGHFK 480 VWVLTDDSDI 490 YKKAIGWTCD 500 FVGSYHKYQA 510 TNCCFSEDGS 520 LLAVSFEEIV 530 TIWDSETWEL 540 KCTFCQRAGK 550 IRHLCFGRLT 560 CSKYLLGTTE 570 NNLLCCWNLL 580 SCSMQWSAKL 590 NVRVMEADPY 600 SDHIAAVARS 610 SEGSDLFVFK 620 PSEPRPLYIQ 630 KNVSREKVQW 640 GVFVPRDVPE 650 SFTSEAHQWL 660 NRSQFYFLTE 670 SQCLLTFSTK 680 YAEEKLTPTS 690 KQLLAEESLP 700 TTPFSFILGK 710 HRQQQDTKST 720 ETSESELVQL 730 PLTENIPAIT 740 ELLHTPAHVL 750 PSASFLCTLF 760 VNSLLLSKET 770 KSAEEISDDV 780 DMEGNEESDD 790 SDEEYDLTEK 800 AKETSNPDLG 810 EDAIHQLSKS 820 EEKELRKFRK VDYSWLTAL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0032040	small-subunit processome
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:2000234	positive regulation of rRNA processing
Biological Process	GO:0045943	positive regulation of transcription by RNA polymerase I
Biological Process	GO:0042274	ribosomal small subunit biogenesis
Biological Process	GO:0006364	rRNA processing

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.