Search Results

Overview

Uniprot ID	A0A0G2K9X3
Protein Name	Unconventional myosin-Va
Gene Name	Myo5a
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
1009	EERADKYKQETEQLV
1224	LRKALSEKSAPEVTA
381	TATETYIKPISKLQA
47	LEYRLDPKTSELPHL
613	RVPVKPTKGRPGQTA

Function

Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Can hydrolyze ATP in the presence of actin, which is essential for its function as a motor protein. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation

Protein Sequence

10 LFARVWIPDP 20 EEVWKSAELL 30 KDYKPGDKVL 40 LLHLEEGKDL 50 EYRLDPKTSE 60 LPHLRNPDIL 70 VGENDLTALS 80 YLHEPAVLHN 90 LRVRFIDSKL 100 IYTYCGIVLV 110 AINPYEQLPI 120 YGEDIINAYS 130 GQNMGDMDPH 140 IFAVAEEAYK 150 QMARDERNQS 160 IIVSGESGAG 170 KTVSAKYAMR 180 YFATVSGSAS 190 EANVEEKVLA 200 SNPIMESIGN 210 AKTTRNDNSS 220 RFGKYIEIGF 230 DKRYRIIGAN 240 MRTYLLEKSR 250 VVFQAEEERN 260 YHIFYQLCAS 270 AKLPEFKMLR 280 LGNADSFHYT 290 KQGGSPMIEG 300 VDDAKEMAHT 310 RQACTLLGIS 320 ESYQMGIFRI 330 LAGILHLGNV 340 GFASRDSDSC 350 TIPPKHEPLI 360 IFCDLMGVDY 370 EEMCHWLCHR 380 KLATATETYI 390 KPISKLQATN 400 ARDALAKHIY 410 AKLFNWIVGH 420 VNQALHSAVK 430 QHSFIGVLDI 440 YGFETFEINS 450 FEQFCINYAN 460 EKLQQQFNMH 470 VFKLEQEEYM 480 KEQIPWTLID 490 FYDNQPCINL 500 IESKLGILDL 510 LDEECKMPKG 520 TDDTWAQKLY 530 NTHLNKCALF 540 EKPRMSNKAF 550 IIKHFADKVE 560 YQCEGFLEKN 570 KDTVFEEQIK 580 VLKSSKFKML 590 PELFQDDEKA 600 ISPTSATSSG 610 RTPLTRVPVK 620 PTKGRPGQTA 630 KEHKKTVGLQ 640 FRNSLHLLME 650 TLNATTPHYV 660 RCIKPNDFKF 670 PFTFDEKRAV 680 QQLRACGVLE 690 TIRISAAGFP 700 SRWTYQEFFS 710 RYRVLMKQKD 720 VLGDRKQTCQ 730 NVLEKLILDK 740 DKYQFGKTKI 750 FFRAGQVAYL 760 EKLRADKLRA 770 ACIRIQKTIR 780 GWLLRKRYLC 790 MQRAAITVQR 800 YVRGYQARCY 810 AKFLRRTKAA 820 TTIQKYWRMY 830 VVRRKYKIRR 840 AATIVLQSYL 850 RGYLARNRYR 860 KILREHKAVI 870 IQKRVRGWLA 880 RTHYKRTMKA 890 IIYLQCCFRR 900 MMAKRELKKL 910 KIEARSVERY 920 KKLHIGMENK 930 IMQLQRKVDE 940 QNKDYKCLME 950 KLTNLEGVYN 960 SETEKLRNDV 970 ERLQLSEEEA 980 KVATGRVLSL 990 QEEIAKLRKD 1000 LEQTRSEKKS 1010 IEERADKYKQ 1020 ETEQLVSNLK 1030 EENTLLKQEK 1040 ETLNHLMVEQ 1050 AKEMTETMER 1060 KLVEETKQLE 1070 LDLNDERLRY 1080 QNLLNEFSRL 1090 EERYDDLKEE 1100 MTLMLNVPKP 1110 GHKRTDSTHS 1120 SNESEYTFSS 1130 EFAETEDIAP 1140 RTEEPTEKKV 1150 PLDMSLFLKL 1160 QKRVTELEQE 1170 KQLMQDELDR 1180 KEEQVLRSKA 1190 KEEERPQIRG 1200 AELEYESLKR 1210 QELESENKKL 1220 KNELNELRKA 1230 LSEKSAPEVT 1240 APGAPAYRVL 1250 MEQLTAVSEE 1260 LDVRKEEVLI 1270 LRSQLVSQKE 1280 AIQPKNTMTD 1290 STILLEDVQK 1300 MKDKGEIAQA 1310 YIGLKETNRL 1320 LESQLQSQKR 1330 SHENEAEALR 1340 GEIQSLKEEN 1350 NRQQQLLAQN 1360 LQLPPEARIE 1370 ASLQHEITRL 1380 TNENLDLMEQ 1390 LEKQDKTVRK 1400 LKKQLKVFAK 1410 KIGELEVGQM 1420 ENISPGQIID 1430 EPIRPVNIPR 1440 KEKDFQGMLE 1450 YKREDEQKLV 1460 KNLILELKPR 1470 GVAVNLIPGL 1480 PAYILFMCVR 1490 HADYLNDDQK 1500 VRSLLTSTIN 1510 SIKKVLKKRG 1520 DDFETVSFWL 1530 SNTCRFLHCL 1540 KQYSGEEGFM 1550 KHNTSRQNEH 1560 CLTNFDLAEY 1570 RQVLSDLAIQ 1580 IYQQLVRVLE 1590 NILQPMIVSG 1600 MLEHETIQGV 1610 SGVKPTGLRK 1620 RTSSIADEGT 1630 YTLDSILRQL 1640 NSFHSVMCQH 1650 GMDPELIKQV 1660 VKQMFYIVGA 1670 ITLNNLLLRK 1680 DMCSWSKGMQ 1690 IRYNVSQLEE 1700 WLRDKNLMNS 1710 GAKETLEPLI 1720 QAAQLLQVKK 1730 KTDDDAEAIC 1740 SMCNALTTAQ 1750 IVKVLNLYTP 1760 VNEFEERVSV 1770 SFIRTIQVRL 1780 RDRKDSPQLL 1790 MDAKHIFPVT 1800 FPFNPSSLAL 1810 ETIQIPASLG LGFIARV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0055037	recycling endosome
Cellular Component	GO:0042641	actomyosin
Cellular Component	GO:0016459	myosin complex
Cellular Component	GO:0043025	neuronal cell body
Cellular Component	GO:0098871	postsynaptic actin cytoskeleton
Cellular Component	GO:0030141	secretory granule
Molecular Function	GO:0003779	actin binding
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0005516	calmodulin binding
Molecular Function	GO:0019899	enzyme binding
Molecular Function	GO:0000146	microfilament motor activity
Biological Process	GO:0018958	phenol-containing compound metabolic process
Biological Process	GO:0043473	pigmentation
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane
Biological Process	GO:0015031	protein transport
Biological Process	GO:0032252	secretory granule localization
Biological Process	GO:0030050	vesicle transport along actin filament

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.