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Overview

Uniprot ID	A0A0G2KA27
Protein Name	MAP kinase-activating death domain protein
Gene Name	Madd
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
1488	INMTYCPKTKVLCLW

Function

Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family. Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion. Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction. Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses. Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals. Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2. May link TNFRSF1A with MAP kinase activation. May be involved in the regulation of TNFA-induced apoptosis

Protein Sequence

10 MVQKKFCPRL 20 LDYLVIVGAR 30 HPSSDSVAQT 40 PELLRRYPLE 50 DHPEFPLPPD 60 VVFFCQPEGC 70 LSVRQRRMSL 80 RDDTSFVFTL 90 TDKDTGVTRY 100 GICVNFYRSF 110 QKRMPKEKAE 120 GGAGPRGKEG 130 AHAPCASEEA 140 ATESSESGST 150 LQPPSADSTP 160 DVNQSPRGKR 170 RAKAGNRSRN 180 STLTSLCVLS 190 HYPFFSTFRE 200 CLYTLKRLVD 210 CCSERLLGKK 220 PGIPRGVQRD 230 TMWRIFTGSL 240 LVEEKSSALL 250 HDLREIEAWI 260 YRLLRSPVPV 270 SGQKRVDIEV 280 LPQEVQQALT 290 FALPDPSRFT 300 LVDFPLHLPL 310 ELLGVDACLQ 320 VLTCILLEHK 330 VVLQSRDYNA 340 LSMSVMAFVA 350 MIYPLEYMFP 360 VIPLLPTCMA 370 SAEQLLLAPT 380 PYIIGVPASF 390 FLYKLDFKMP 400 DDVWLVDLDS 410 NRVIAPTNAE 420 VLPILPEPES 430 LELKKHLKQA 440 LASMSLNTQP 450 ILNLEKFHEG 460 QETPLLLGRF 470 SNDLQSTPST 480 EFNPLIYGND 490 VDSVDVATRV 500 AMVRFFNSAN 510 VLQGFQMHTR 520 TLRLFPRPVV 530 AFQAGSFLAS 540 RPRQTPFAEK 550 LARTQAVEYF 560 GEWILNPSNY 570 AFQRIHNNTF 580 DPALIGDKPK 590 WYAHQLQPIH 600 YRVYDSNSQL 610 AEALSVPPER 620 DSESDPTDDS 630 GSDSMDYDDS 640 SSSYSSLGDF 650 VSEMMKCDIN 660 GDTPNVDPLT 670 HAALGDASEV 680 EIDELQPQKE 690 GEEPGPDSEN 700 SQENLPLRSS 710 SSTTASSSPS 720 TIVHGAHSEP 730 ADSTEVGDKA 740 ATGISKPLPP 750 VPPSICKSTV 760 DRRQTETGEG 770 SVCQRTYDHP 780 YFEPQYGSPA 790 EEDDDEQGES 800 YTPRFSQHAS 810 GSRAQKLLRP 820 NSLKLASDSD 830 AESDSRASSP 840 NSTVSNNSTE 850 GFGGIMSFAS 860 SLYRNHSTSF 870 SLSNLTLPTK 880 GAREKTTPFP 890 SLKVFGLNTL 900 MEIVTEAGPG 910 SGEGNRRALV 920 DQKSSVIKHS 930 PTVKREPPSP 940 QGRSSNSSEN 950 QQFLKEVVHS 960 VLDGQGVGWL 970 NMKKVRRLLE 980 SEQLRVFVLS 990 KLSRAVQSED 1000 DARQDVIQDV 1010 EISRKVYKGM 1020 LDLLKCTVLS 1030 LEQSYAHAGL 1040 GGMASIFGLL 1050 EIAQTHYYSK 1060 EPDKRKRSPT 1070 ENVNTPVGKD 1080 PGLAGRGDPK 1090 AMAQLRVPQL 1100 GPRAPSATGR 1110 GPKELDTRSL 1120 KEENFVASVE 1130 LWNKHQEVKK 1140 QKALEKQRPE 1150 VIKPVFDLGE 1160 TEEKKSQISA 1170 DSGVSLASAS 1180 QRTDQDSVIG 1190 VSPAVMIRSS 1200 SQDSEVSTVV 1210 SNSSGETLGA 1220 DSDLSSNAGD 1230 GPGGEGSAHL 1240 ASSRATLSDS 1250 EIETNSATST 1260 IFGKAHSLKP 1270 KEKPASSPVR 1280 SSEDVSQRVY 1290 LYEGLLGRDK 1300 GSMWDQLEDA 1310 AMETFSISKE 1320 RSTLWDQMQF 1330 WEDAFLDAVM 1340 LEREGMGMDQ 1350 GPQEMIDRYL 1360 SLGEHDRKRL 1370 EDDEDRLLAT 1380 LLHNLISYML 1390 LMKVNKNDIR 1400 KKVRRLMGKS 1410 HVGLVYSQQI 1420 NEVLDQLTNL 1430 NGRDLSIRSS 1440 GSRHMKKQTF 1450 VVHAGTDTNG 1460 DIFFMEVCDD 1470 CVVLRSNIGT 1480 VYERWWYEKL 1490 INMTYCPKTK 1500 VLCLWRRNGS 1510 ETQLNKFYTK 1520 KCRELYYCVK 1530 DSMERAAARQ 1540 QSIKPGPELG 1550 GEFPVQDMKT 1560 GEGGLLQVTL 1570 EGINLKFMHN 1580 QVFIELNHIK 1590 KCNTVRGVFV 1600 LEEFVPEIKE 1610 VVSHKYKTPM 1620 AHEICYSVLC 1630 LFSYVAAVRS 1640 SEEDLRTPPR PVSS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity
Biological Process	GO:0006915	apoptotic process

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.