Overview
| Uniprot ID | A0A0G2KAZ7 |
|---|
| Protein Name | Heterogeneous nuclear ribonucleoprotein D-like |
|---|
| Gene Name | Hnrnpdl |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 311 |
EIKVAQPKEVYRQQQ |
| 91 |
DLFRRHFKSSSIQRS |
Function
Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes. Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter. Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence
Protein Sequence
10
MEVPPRLSHV
20
PPPLFPSAPA
30
TLASRSLSHW
40
RPRAPRQLAP
50
LLPSLASSSS
60
RQGARRTQRH
70
VTAQQPSRLA
80
GGAAIKGGRR
90
RRPDLFRRHF
100
KSSSIQRSAA
110
AAPGTRTARQ
120
HPLADGSATM
130
EDMNEYSNIE
140
EFAEGSKINA
150
SKNQQDDGKM
160
FIGGLSWDTS
170
KKDLTEYLSR
180
FGEVVDCTIK
190
TDPVTGRSRG
200
FGFVLFKDAA
210
SVDKVLELKE
220
HKLDGKLIDP
230
KRAKALKGKE
240
PPKKVFVGGL
250
SPDTSEEQIK
260
EYFGAFGEIE
270
NIELPMDTKT
280
NERRGFCFIT
290
YTDEEPVKKL
300
LESRYHQIGS
310
GKCEIKVAQP
320
KEVYRQQQQQ
330
QKGGRGAAAG
340
GRGGARGRGR
350
GQGQNWNQGF
360
NNYYDQGYGN
370
YNSAYGDESY
380
SGYGGYDYTG
390
YNYGSYGYGQ
400
GYTDYSGQQS
410
TYGKASRGGG
NHQNNYQPY
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Molecular Function |
GO:0003677 |
DNA binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.