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Overview

Uniprot ID	A0A0G2KB58
Protein Name	Serine/threonine-protein kinase MRCK beta
Gene Name	Cdc42bpb
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
426	IQSNTLTKDEDVQRD

Function

Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A. In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation

Protein Sequence

10 MSAKVRLKKL 20 EQLLLDGPWR 30 NESSLSVETL 40 LDVLVCLYTE 50 CSHSALRRDK 60 YVAEFLEWAK 70 PFTQLVKDMQ 80 LHREDFEIIK 90 VIGRGAFGEV 100 AVVKMKNTER 110 IYAMKILNKW 120 EMLKRAETAC 130 FREERDVLVN 140 GDCQWITALH 150 YAFQDENYLY 160 LVMDYYVGGD 170 LLTLLSKFED 180 KLPEDMARFY 190 IGEMVLAIDS 200 IHQLHYVHRD 210 IKPDNVLLDV 220 NGHIRLADFG 230 SCLKMNDDGT 240 VQSSVAVGTP 250 DYISPEILQA 260 MEDGMGKYGP 270 ECDWWSLGVC 280 MYEMLYGETP 290 FYAESLVETY 300 GKIMNHEERF 310 QFPSHVTDVS 320 EEAKDLIQRL 330 ICSRERRLGQ 340 NGIEDFKKHA 350 FFEGLNWENI 360 RNLEAPYIPD 370 VSSPSDTSNF 380 DVDDDVLRNI 390 EILPPGSHTG 400 FSGLHLPFIG 410 FTFTTESCFS 420 DRGSLKSMIQ 430 SNTLTKDEDV 440 QRDLENSLQI 450 EAYERRIRRL 460 EQEKLELSRK 470 LQESTQTVQS 480 LHGSTRALGN 490 SNRDKEIKRL 500 NEELERMKSK 510 MADSNRLERQ 520 LEDTVTLRQE 530 HEDSTQRLKG 540 LEKQYRLARQ 550 EKEELHKQLV 560 EASERLKSQT 570 KELKDAHQQR 580 KRALQEFSEL 590 NERMAELRSQ 600 KQKVSRQLRD 610 KEEEMEVAMQ 620 KIDSMRQDIR 630 KSEKSRKELE 640 ARLEDAVAEA 650 SKERKLREHS 660 ESFSKQMERE 670 LETLKVKQGG 680 RGPGATLEHQ 690 QEISKIRSEL 700 EKKVLFYEEE 710 LVRREASHVL 720 EVKNVKKEVH 730 ESESHQLALQ 740 KEVLMLKDKL 750 EKSKRERHSE 760 MEEAIGAMKD 770 KYERERAMLF 780 DENKKLTAEN 790 EKLCSFVDKL 800 TAQNRQLEDE 810 LQDLASKKES 820 VAHWEAQIAE 830 IIQWVSDEKD 840 ARGYLQALAS 850 KMTEELETLR 860 SSSLGSRTLD 870 PLWKVRRSQK 880 LDMSARLELQ 890 SALEAEIRAK 900 QLVHEELRKV 910 KDTSLAFESK 920 LKESEAKNRE 930 LLEEMQSLKK 940 RMEEKFRADT 950 GLKLPDFQDP 960 IFEYFNTAPL 970 AHDLTFRTSS 980 ASDQETQASK 990 LDLSPSVSVA 1000 TSTEQQEDAA 1010 RSQQRPSTVP 1020 LPNTQALAMA 1030 GPKPKAHQFS 1040 IKSFPSPTQC 1050 SHCTSLMVGL 1060 IRQGYACEVC 1070 AFSCHVSCKD 1080 SAPQVCPIPP 1090 EQSKRPLGVD 1100 VQRGIGTAYK 1110 GYVKVPKPTG 1120 VKKGWQRAYA 1130 VVCDCKLFLY 1140 DLPEGKSTQP 1150 GVIASQVLDL 1160 RDDEFAVSSV 1170 LASDVIHATR 1180 RDIPCIFRVT 1190 ASLLGSPSKT 1200 SSLLILTENE 1210 NEKRKWVGIL 1220 EGLQAILHKN 1230 RLRSQVVHVA 1240 QEAYDSSLPL 1250 IKTVLAAAIV 1260 DGDRIAVGLE 1270 EGLYVIELTR 1280 DVIVRAADCK 1290 KVYQIELAPK 1300 EKLILLLCGR 1310 NHHVHLYPWT 1320 SFDGAEASNF 1330 DIKLPETKGC 1340 QLIATGTLRK 1350 SSSTCLFVAV 1360 KRLVLCYEIQ 1370 RTKPFHRKFN 1380 EIVAPGHVQW 1390 MAMFKDRLCV 1400 GYPSGFSLLS 1410 IQGDGQPLDL 1420 VNPADPSLAF 1430 LSQQSFDALC 1440 AVELKSEEYL 1450 LCFSHMGLYV 1460 DPQGRRSRTQ 1470 ELMWPAAPVA 1480 CSCSSSHVTV 1490 YSEYGVDVFD 1500 VRTMEWVQTI 1510 GLRRIRPLNS 1520 DGSLNLLGCE 1530 PPRLIYFKNK 1540 FSGTVLNVPD 1550 TSDNSKKQML 1560 RTRSKRRFVF 1570 KVPEEERLQQ 1580 RREMLRDPEL 1590 RSKMISNPTN 1600 FNHVAHMGPG 1610 DGMQVLMDLP 1620 LVRAQPGSGN 1630 SIPHDPLGGS 1640 EPGVPVPLRS 1650 MSDPDQDFDK 1660 EVCVPHTRLR 1670 PTAPTLAAPR 1680 APTHRTGASS 1690 LWKAWTSQPA TPEAASIAP

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0042641	actomyosin
Cellular Component	GO:0070161	anchoring junction
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0030027	lamellipodium
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0004674	protein serine/threonine kinase activity
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0031032	actomyosin structure organization
Biological Process	GO:0016477	cell migration

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.