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Overview

Uniprot ID	A0A0G2KB63
Protein Name	Prohibitin
Gene Name	Phb2
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
244	MLGEALSKNPGYIKL
262	RAAQNISKTIATSQN

Function

In the mitochondria, together with PHB, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan. The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner. Also regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration. Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity. Has a key role of mitophagy receptor involved in targeting mitochondria for autophagic degradation. Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6

Protein Sequence

10 MAQNLKDLAG 20 RLPSGPRGMG 30 TALKLLLGAG 40 AVAYGVRESV 50 FTVEGGHRAI 60 FFNRIGGVQQ 70 DTILAEGLHF 80 RIPWFQYPII 90 YDIRARPRKI 100 SSPTGSKDLQ 110 MVNISLRVLS 120 RPNAQELPSM 130 YQRLGLDYEE 140 RVLPSIVNEV 150 LKSVVAKFNA 160 SQLITQRAQV 170 SLLIRRELTE 180 RAKDFSLILD 190 DVAITELSFS 200 REYTAAVEAK 210 QVAQQEAQRA 220 QFLVEKAKQE 230 QRQKIVQAEG 240 EAEAAKMLGE 250 ALSKNPGYIK 260 LRKIRAAQNI 270 SKTIATSQNR 280 IYLTADNLVL 290 NLQDESFTRD SLIKGKK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005743	mitochondrial inner membrane

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.