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Overview

Uniprot IDA0A0G2KBC7
Protein NameATP-dependent 6-phosphofructokinase
Gene NamePfkm
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
178 RAAHNLVKRGITNLC
547 TKRTLPKKNLEQISA
749 FDRNFATKMGAKAMN
825 PILKILAKYEIDLDT

Function

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis

Protein Sequence

10 MRKDEFHLRF 20 FMCVFESRHV 30 VRTTQSTAGE 40 ASSSNMIIQM 50 PQSKADFLEK 60 LESVDDPNTV 70 GHVPILETEW 80 IMTHEEHHEA 90 KTLGIGKAIA 100 VLTSGGDAQG 110 MNAAVRAVVR 120 VGIFTGARVF 130 FVHEGYQGLV 140 DGGEHIREAT 150 WESVSMMLQL 160 GGTVIGSARC 170 KDFREREGRL 180 RAAHNLVKRG 190 ITNLCVIGGD 200 GSLTGADTFR 210 SEWSDLLNDL 220 QKDGKITAEE 230 ATKSSYLNIV 240 GLVGSIDNDF 250 CGTDMTIGTD 260 SALHRIVEIV 270 DAITTTAQSH 280 QRTFVLEVMG 290 RHCGYLALVT 300 SLSCGADWVF 310 IPECPPDDDW 320 EEHLCRRLSE 330 TRTRGSRLNI 340 IIVAEGAIDK 350 NGKPITSEDI 360 KNLVVKRLGY 370 DTRVTVLGHV 380 QRGGTPSAFD 390 RILGSRMGVE 400 AVMALLEGTP 410 DTPACVVSLS 420 GNQAVRLPLM 430 ECVQVTKDVT 440 KAMDEKRFDE 450 AIKLRGRSFM 460 NNWEVYKLLA 470 HVRPPVSKGG 480 LHTVAVMNVG 490 APAAGMNAAV 500 RSTVRIGLIQ 510 GNRVLVVHDG 520 FEGLAKGQIE 530 EAGWSYVGGW 540 TGQGGSKLGT 550 KRTLPKKNLE 560 QISANITKYN 570 IQGLVIIGGF 580 EAYTGGLELM 590 EGRKQFDELC 600 IPFVVIPATV 610 SNNVPGSDFS 620 IGADTALNTI 630 CTTCDRIKQS 640 AAGTKRRVFI 650 IETMGGYCGY 660 LATMAGLAAG 670 ADAAYIFEEP 680 FTIRDLQVNV 690 EHLVQKMKTT 700 VKRGLVLRNE 710 KCNENYTTDF 720 IFNLYSEEGK 730 GIFDSRKNVL 740 GHMQQGGSPT 750 PFDRNFATKM 760 GAKAMNWMSG 770 KIKESYRNGR 780 IFANTPDSGC 790 VLGMRKRALV 800 FQPVTELKDQ 810 TDFEHRIPKE 820 QWWLKLRPIL 830 KILAKYEIDL 840 DTSDHAHLEH 850 ISRKRSGEAA V

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005945 6-phosphofructokinase complex
Cellular Component GO:0016324 apical plasma membrane
Cellular Component GO:0005634 nucleus
Cellular Component GO:0097228 sperm principal piece
Molecular Function GO:0003872 6-phosphofructokinase activity
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0070061 fructose binding
Molecular Function GO:0070095 fructose-6-phosphate binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0019900 kinase binding
Molecular Function GO:0046872 metal ion binding
Biological Process GO:0061621 canonical glycolysis
Biological Process GO:0030388 fructose 1,6-bisphosphate metabolic process
Biological Process GO:0006002 fructose 6-phosphate metabolic process
Biological Process GO:0046716 muscle cell cellular homeostasis
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.