Search Results

Overview

Uniprot IDA0A0G2QC02
Protein NameSuperkiller complex protein 2
Gene NameSkic2
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
528 AKKERMSKHAQTFGA

Function

Helicase component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways. The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation. SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling. In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C). May play a role in the non-stop mRNA decay pathway (NSD), which specifically targets and degrades mRNAs that lack a proper stop codon

Protein Sequence

10 MMETERLVLP 20 PPDPLNLPLR 30 ALEVGCTGRW 40 ELLNVPGPPE 50 STLPHGLPPC 60 APDLCQEAEQ 70 LFLSSPAWLP 80 LHGVEHSARK 90 WQRKTDPWSL 100 LAALGTPVPS 110 DLQAQRHPTT 120 GHILGYKEVL 130 LENTNLSATT 140 SLSLRRPPGP 150 ASQSLWGNPT 160 QYPFWPGGMD 170 EPSITDLSTR 180 EEAEEEIDFE 190 KDLLTVPPGF 200 KKGVDFAPKD 210 HPAPVPGLLS 220 LSRLLEPLDL 230 SGGDEGEGEA 240 AGGPRGDAAS 250 ASPSSTPLIR 260 ASSLEDLVLK 270 EASTVVSTLE 280 PLKPPPQEQW 290 AVPVDVTSPV 300 GDFYRLIPQP 310 AFQWAFEPDV 320 FQKQAILHLE 330 QHDSVFVAAH 340 TSAGKTVVAE 350 YAIALAQKHM 360 TRTIYTSPIK 370 ALSNQKFRDF 380 RNTFGDVGLL 390 TGDVQLHPEA 400 SCLIMTTEIL 410 RSMLYSGSDV 420 IRDLEWVIFD 430 EVHYINDAER 440 GVVWEEVLIM 450 LPEHVSIILL 460 SATVPNALEF 470 ADWIGRLKRR 480 QIYVISTVAR 490 PVPLEHYLFT 500 GNSPKTQGEL 510 FLLLDSRGAF 520 HTKGYYAAVE 530 AKKERMSKHA 540 QTFGAKQPTH 550 QGGPAQDRGV 560 YLALLASLRT 570 RAQLPVVVFT 580 FSRGRCDEQA 590 SGLTSLDLTT 600 SSEKSEIHLF 610 LQRCLARLRG 620 SDRQLPQVLH 630 MSELLRRGLG 640 VHHSGILPIL 650 KEIVEMLFSR 660 GLVKVLFATE 670 TFAMGVNMPA 680 RTVVFDSMRK 690 HDGSTFRDLL 700 PGEYVQMAGR 710 AGRRGLDPTG 720 TVILLCKGRV 730 PEMADLHRMM 740 MGKPSQLQSQ 750 FRLTYTMILN 760 LLRVDALRVE 770 DMMKRSFSEF 780 PSRKDSKAHE 790 QALADLTKRL 800 GALEEPDVTG 810 QLADLPEYYS 820 WAEELTETRN 830 MIQVSSNSTS 840 RVFTTLVLCD 850 KPAVSENPRD 860 KGPATPDVPH 870 PDDLVGFKLF 880 LPEGPCEHTV 890 AKLQPGDVAA 900 ISTKVLRVNG 910 EKISEDFSKR 920 QQPKFRKDPP 930 LAAVTTAVQE 940 LLRLAQAYPA 950 GPPTLDPIND 960 LQLKDVAVVE 970 GGLRARKLEE 980 LIRGAQCVHS 990 PRFPAQYVKL 1000 QERMQIQKEM 1010 ERLRFLLSDQ 1020 SLLLLPEYHQ 1030 RVEVLRTLGY 1040 VDEAGTVKLA 1050 GRVACAMSSH 1060 ELLLTELMFD 1070 NALSALRPEE 1080 IAALLSGLVC 1090 QSPGDPGDQL 1100 PSTLKQGVER 1110 VKAVAKRIGE 1120 VQVACGLNQT 1130 VEEFVGELNF 1140 GLVEVVYEWA 1150 RGMPFSELAG 1160 LSGTPEGLVV 1170 RCIQRLAEMC 1180 RSLRGAARLV 1190 GEPVLGAKME 1200 TAATLLRRDI VFAASLYTQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0055087 Ski complex
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016787 hydrolase activity
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0003724 RNA helicase activity
Biological Process GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.