Search Results

Overview

Uniprot IDA0A0G2QC17
Protein Name[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
Gene NamePdp1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
351 ERELERLKLEHPKNE

Function

Mitochondrial enzyme that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (PDC), thereby stimulating the conversion of pyruvate into acetyl-CoA

Protein Sequence

10 MCVCPGPRRI 20 GIPVRTSSLP 30 LFSDAMPAPT 40 QLFFPLVRNC 50 ELSRIYGTAC 60 YCHHKHLCCS 70 PPYIPQNRLR 80 YTPHPAYATF 90 CRPRENWWQY 100 TQGRRYASTP 110 QKFYLTPPQV 120 NSILKANEYS 130 FKVPEFDGKN 140 VSSILGFDSN 150 QLPANAPIED 160 RRSAATCLQT 170 RGMLLGVFDG 180 HAGCACSQAV 190 SERLFYYIAV 200 SLLPHETLLE 210 IENAVESGRA 220 LLPILQWHKH 230 PNDYFSKEAS 240 KLYFNSLRTY 250 WQELIDLNTG 260 ESADIDVKEA 270 LINAFKRLDN 280 DISLEAQVGD 290 PNSFLNYLVL 300 RVAFSGATAC 310 VAHVDGVDLH 320 VANTGDSRAM 330 LGVQEEDGSW 340 SAVTLSNDHN 350 AQNERELERL 360 KLEHPKNEAK 370 SVVKQDRLLG 380 LLMPFRAFGD 390 VKFKWSIDLQ 400 KRVIESGPDQ 410 LNDNEYTKFI 420 PPNYHTPPYL 430 TAEPEVTYHR 440 LRPQDKFLVL 450 ATDGLWETMH 460 RQDVVRIVGE 470 YLTGMHHQQP 480 IAVGGYKVTL 490 GQMHGLLTER 500 RAKMSSVFED 510 QNAATHLIRH 520 AVGNNEFGAV 530 DHERLSKMLS 540 LPEELARMYR 550 DDITIIVVQF 560 NSHVVGAYQN QEQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0004741 [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity
Molecular Function GO:0046872 metal ion binding

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.