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Overview

Uniprot IDA0A0H2UHB7
Protein NameAnion exchange protein
Gene NameSlc4a4
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
1077 SPPRSPVKVVPQIRI
177 ELRTCMEKGSIMLDR
239 RSLADIGKTVSSASR
25 DRGASFLKHVCDEEE
345 LGPKGKAKSYHEIGR

Function

Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH

Protein Sequence

10 MYRCLLLNLV 20 MEDEAVLDRG 30 ASFLKHVCDE 40 EEVEGHHTIY 50 IGVHVPKSYR 60 RRRRHKRKAG 70 HKEKKEKERI 80 SENYSDKSDV 90 ENADESSSSI 100 LKPLISPAAE 110 RIRFILGEED 120 DSPAPPQLFT 130 ELDELLAVDG 140 QEMEWKETAR 150 WIKFEEKVEQ 160 GGERWSKPHV 170 ATLSLHSLFE 180 LRTCMEKGSI 190 MLDREASSLP 200 QLVEMIADHQ 210 IETGLLKPDL 220 KDKVTYTLLR 230 KHRHQTKKSN 240 LRSLADIGKT 250 VSSASRMFSN 260 PDNGSPAMTH 270 RNLTSSSLND 280 ISDKPEKDQL 290 KNKFMKKLPR 300 DAEASNVLVG 310 EVDFLDTPFI 320 AFVRLQQAVM 330 LGALTEVPVP 340 TRFLFILLGP 350 KGKAKSYHEI 360 GRAIATLMSD 370 EVFHDIAYKA 380 KDRHDLIAGI 390 DEFLDEVIVL 400 PPGEWDPAIR 410 IEPPKSLPSS 420 DKRKNMYSGG 430 ENVQMNGDTP 440 HDGGHGGGGH 450 GDCEELQRTG 460 RFCGGLIKDI 470 KRKAPFFASD 480 FYDALNIQAL 490 SAILFIYLAT 500 VTNAITFGGL 510 LGDATDNMQG 520 VLESFLGTAV 530 SGAIFCLFAG 540 QPLTILSSTG 550 PVLVFERLLF 560 NFSKDHSFDY 570 LEFRLWIGLW 580 SAFMCLILVA 590 TDASFLVQYF 600 TRFTEEGFSS 610 LISFIFIYDA 620 FKKMIKLADY 630 YPINSDFRVG 640 YNTHFSCACL 650 PPDPVNLSVS 660 NDTTLAPEDL 670 PTVSSTDMYH 680 NATFDWAYLS 690 KKECVKFGGK 700 LVGNNCDFVP 710 DITLMSFILF 720 LGTYTSSMAM 730 KKFKTSRYFP 740 TTARKLISDF 750 AIILSILIFC 760 VIDALVGVDT 770 PKLIVPSEFK 780 PTSPHRGWFV 790 PPFGGNPWWV 800 CLAAAIPALL 810 VTILIFMDQQ 820 ITAVIVNRKE 830 HKLKKGAGYH 840 LDLFWVAILM 850 VVCSFMALPW 860 YVAATVISIA 870 HIDSLKMETE 880 TSAPGEQPKF 890 LGVREQRVTG 900 TLVFILTGLS 910 VFMAPILKFI 920 PMPVLYGVFL 930 YMGVASLNGV 940 QFMDRLKLLL 950 MPLKHQPDFI 960 YLRHVPLRRV 970 HLFTSLQVLC 980 LALLWILKST 990 VAAIIFPVMI 1000 LALVAVRKGM 1010 DYLFSQHDLS 1020 FLDDVIPEKD 1030 KKKKEDEKKK 1040 KKKKGSLDSD 1050 NDDEKDPQHS 1060 LNATHHADKI 1070 PFLESLGLPS 1080 PPRSPVKVVP 1090 QIRIELESED 1100 NDYLWRNKGT ETTL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016323 basolateral plasma membrane
Molecular Function GO:0008509 monoatomic anion transmembrane transporter activity
Molecular Function GO:0008510 sodium:bicarbonate symporter activity
Molecular Function GO:0005452 solute:inorganic anion antiporter activity
Biological Process GO:0055080 monoatomic cation homeostasis

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.