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Overview

Uniprot ID	A0A0H2UHC0
Protein Name	Rho GTPase-activating protein 44
Gene Name	Arhgap44
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
158	SLQPAGAKADALREE
629	TLRKVSKKLAPIPPK

Function

GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1. In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity. Limits the initiation of exploratory dendritic filopodia. Recruited to actin-patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contractile forces. Acts through GAP activity on RAC1 to reduce actin polymerization necessary for filopodia formation. In association with SHANK3, promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation

Protein Sequence

10 RAEKTEVLSE 20 DLLQVEKRLE 30 LVKQVSHSTH 40 KKLTACLQGQ 50 QGAEADKRSK 60 KLPLTTLAQC 70 LMEGSAILGD 80 DTLLGKMLKL 90 CGETEDELAQ 100 ELIHFELRVE 110 RDVIEPLFLL 120 AEVEIPNIQK 130 QRKHLAKLVL 140 DMDSSRTRWQ 150 QTSKSSGLSS 160 SLQPAGAKAD 170 ALREEMEEAA 180 NRVEICRDQL 190 SADMYSFVAK 200 EIDYANYFQT 210 LIEVQAEYHR 220 KSLTLLQAVL 230 PQIKAQQEAW 240 VEKPSFGKPL 250 EEHLMISGRE 260 IAFPIEACVT 270 MLLECGMQEE 280 GLFRVAPSAS 290 KLKKLKAALD 300 CCVVDVQEYS 310 ADPHAIAGAL 320 KSYLRELPEP 330 LMTFELYDEW 340 IQASNIQEQD 350 KRLQALWNAC 360 EKLPKANHNN 370 IRYLIKFLSK 380 LSEYQDVNKM 390 TPSNMAIVLG 400 PNLLWPQSEG 410 NITEMMTTVS 420 LQIVGIIEPI 430 IQHADWFFPG 440 EIEFNITGSY 450 GSPVHVNHNA 460 NYSSMPSPDM 470 DPADRRQPEQ 480 ARRPLSVATD 490 NMMLEFYKKD 500 GLRKIQSMGV 510 RVMDTSWVAR 520 RGSSAGRKAA 530 CAPPSMQPPA 540 PPSELAAPLP 550 SPLPEQVPDS 560 PATPAPALSP 570 SGASLQPTPE 580 RPSVSKSKEL 590 SPGSGQKGSP 600 GSIQGTTCPG 610 TQLGPQPAAS 620 PSQLPADQSP 630 HTLRKVSKKL 640 APIPPKVPFV 650 QPGTVSDQPT 660 GQPSPVSLSP 670 TPPSTPSPYG 680 LSYPPGYSMA 690 SGQLSPASAP 700 PLASPSVFTS 710 TLAKSRPTPK 720 PRQRPTLPPP 730 QPPSVSLSAS 740 SPQSTEHPML 750 DGMSPGESMS 760 TDLVHFDVPS 770 IHIELGSTLR 780 LSPLEHARRH 790 SVTDKRDSEE ESESTAL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0043197	dendritic spine
Cellular Component	GO:0098793	presynapse
Cellular Component	GO:0055037	recycling endosome
Molecular Function	GO:0005096	GTPase activator activity
Biological Process	GO:0007165	signal transduction

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.