Search Results

Overview

Uniprot ID	A0A0H2UHE1
Protein Name	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
Gene Name	Suclg1
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
104	VGGTTPGKGGKKHLG
108	TPGKGGKKHLGLPVF
119	LPVFNTVKEAKEKTG
322	GAIIAGGKGGAKEKI
62	GSYTASRKNIYIDKN
68	RKNIYIDKNTKVICQ
71	IYIDKNTKVICQGFT
80	ICQGFTGKQGTFHSQ

Function

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. Also able to act as an itaconyl- and malyl-CoA synthetase

Protein Sequence

10 MPRSWGGPES 20 VIGGMTAAVV 30 AAAATATMVS 40 GSSGLAAARL 50 LSRTFLLQQN 60 GIRHGSYTAS 70 RKNIYIDKNT 80 KVICQGFTGK 90 QGTFHSQQAL 100 EYGTKLVGGT 110 TPGKGGKKHL 120 GLPVFNTVKE 130 AKEKTGATAS 140 VIYVPPPFAA 150 AAINEAIDAE 160 IPLVVCITEG 170 IPQQDMVRVK 180 HKLTRQGKTR 190 LIGPNCPGII 200 NPGECKIGIM 210 PGHIHKKGRI 220 GIVSRSGTLT 230 YEAVHQTTQV 240 GLGQSLCIGI 250 GGDPFNGTNF 260 IDCLDVFLKD 270 PATEGIVLIG 280 EIGGHAEENA 290 AEFLKEHNSG 300 PKAKPVVSFI 310 AGITAPPGRR 320 MGHAGAIIAG 330 GKGGAKEKIS 340 ALQSAGVIVS 350 MSPAQLGTCM 360 YKEFEKRKML

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0045244	succinate-CoA ligase complex (GDP-forming)
Molecular Function	GO:0000166	nucleotide binding
Molecular Function	GO:0004775	succinate-CoA ligase (ADP-forming) activity
Molecular Function	GO:0004776	succinate-CoA ligase (GDP-forming) activity
Biological Process	GO:0006099	tricarboxylic acid cycle

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.