Overview
| Uniprot ID | A0A0H2UHL5 |
|---|
| Protein Name | Arp2/3 complex 34 kDa subunit |
|---|
| Gene Name | Arpc2 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 117 |
VHQAGMLKRNCFASV |
| 136 |
FQFQEEGKEGENRAV |
| 186 |
KVFMQEFKEGRRASH |
| 295 |
EMKTITGKTFSSR** |
| 65 |
SISLKFYKELQAHGA |
Function
Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the mother actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs)
Protein Sequence
10
MILLEVNNRI
20
IEETLALKFE
30
NAAAGNKPEA
40
VEVTFADFDG
50
VLYHISNPNG
60
DKTKVMVSIS
70
LKFYKELQAH
80
GADELLKRVY
90
GSFLVNPESG
100
YNVSLLYDLE
110
NLPASKDSIV
120
HQAGMLKRNC
130
FASVFEKYFQ
140
FQEEGKEGEN
150
RAVIHYRDDE
160
TMYVESKKDR
170
VTVVFSTVFK
180
DDDDVVIGKV
190
FMQEFKEGRR
200
ASHTAPQVLF
210
SHREPPLELK
220
DTDAAVGDNI
230
GYITFVLFPR
240
HTNATARDNT
250
INLIHTFRDY
260
LHYHIKCSKA
270
YIHTRMRAKT
280
SDFLKVLNRA
290
RPDAEKKEMK
300
TITGKTFSSR
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005885 |
Arp2/3 protein complex |
| Cellular Component |
GO:0005768 |
endosome |
| Cellular Component |
GO:0005925 |
focal adhesion |
| Cellular Component |
GO:0098978 |
glutamatergic synapse |
| Cellular Component |
GO:0030027 |
lamellipodium |
| Cellular Component |
GO:0036195 |
muscle cell projection membrane |
| Cellular Component |
GO:0043005 |
neuron projection |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0098794 |
postsynapse |
| Cellular Component |
GO:0030672 |
synaptic vesicle membrane |
| Molecular Function |
GO:0051015 |
actin filament binding |
| Molecular Function |
GO:0005200 |
structural constituent of cytoskeleton |
| Biological Process |
GO:0030041 |
actin filament polymerization |
| Biological Process |
GO:0034314 |
Arp2/3 complex-mediated actin nucleation |
| Biological Process |
GO:0010592 |
positive regulation of lamellipodium assembly |
| Biological Process |
GO:0031334 |
positive regulation of protein-containing complex assembly |
| Biological Process |
GO:0030833 |
regulation of actin filament polymerization |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.