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Overview

Uniprot IDA0A0H2UHL9
Protein NameDrebrin
Gene NameDbn1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
173 TDAAVEMKRINREQF
238 QIEEHRRKQQSLEAE
248 SLEAEEAKRRLKDQS
252 EEAKRRLKDQSIFGD
270 EEEESQMKKSESEVE
437 LDGEEVCKEAKVAAA

Function

Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections. Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS. Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines. Involved in memory-related synaptic plasticity in the hippocampus

Protein Sequence

10 MAGVSFSGHR 20 LELLAAYEEV 30 IREESAADWA 40 LYTYEDGSDD 50 LKLAASGEGG 60 LQELSGHFEN 70 QKVMYGFCSV 80 KDSQAALPKY 90 VLINWVGEDV 100 PDARKCACAS 110 HVAKVAEFFQ 120 GVDVIVNASS 130 VEDIDAGAIG 140 QRLSNGLARL 150 SSPVLHRLRL 160 REDENAEPVG 170 TTYQKTDAAV 180 EMKRINREQF 190 WEQAKKEEEL 200 RKEEERKKAL 210 DARLRFEQER 220 MEQERQEQEE 230 RERRYREREQ 240 QIEEHRRKQQ 250 SLEAEEAKRR 260 LKDQSIFGDQ 270 RDEEEESQMK 280 KSESEVEEAA 290 AIIAQRPDNP 300 REFFRQQERV 310 ASASGGSCDA 320 PSPFNHRPGR 330 PYCPFIKASD 340 SGPSSSSSSS 350 SSPPRTPFPY 360 ITCHRTPNLS 370 SSLPCSHLDS 380 HRRMAPTPIP 390 TRSPSDSSTA 400 STPITEQIER 410 ALDEVTSSQP 420 PPPPPPPPPA 430 QEAQESAPRL 440 DGEEVCKEAK 450 VAAAPQVWAG 460 CAEEPPRAQE 470 PPLLQSSPTE 480 DLMCTESPEQ 490 AVLAASPEPD 500 ASVTSVADAH 510 AADTIETTTA 520 TTATTIADNV 530 TPAAASLIDL 540 WPGNGEEAST 550 PQAEPRVPTP 560 PSGAEASLAE 570 VPLLNEAAQE 580 PLPPVGEGCA 590 NLLNFDELPE 600 PPATFCDPEE 610 EAEGEPLAAS 620 QVLTMPSALE 630 EVDQVLEQEL 640 EPEPHLLTNG 650 ETTQKEGTQA 660 SEGYFSQSQE 670 EEFAQSEEPC 680 AKAPPPVFYN 690 KPPEIDITCW 700 DADPVPEEEE GFEGGD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0030425 dendrite
Cellular Component GO:0005921 gap junction
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0030426 growth cone
Cellular Component GO:0099524 postsynaptic cytosol
Cellular Component GO:0014069 postsynaptic density
Cellular Component GO:0045211 postsynaptic membrane
Molecular Function GO:0003779 actin binding
Molecular Function GO:0140311 protein sequestering activity
Biological Process GO:0048699 generation of neurons
Biological Process GO:0061351 neural precursor cell proliferation
Biological Process GO:0061003 positive regulation of dendritic spine morphogenesis
Biological Process GO:1902685 positive regulation of receptor localization to synapse
Biological Process GO:0031915 positive regulation of synaptic plasticity

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.