Search Results
Overview
| Uniprot ID | A0A0H2UHN0 |
|---|---|
| Protein Name | Neuropeptide S receptor |
| Gene Name | Npsr1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 161 | MKFLQGEKQAKVLIG |
Function
G-protein coupled receptor for neuropeptide S (NPS). Receptor activation by NPS initiates a G(q)/GNAQ-dependent phospholipase C-activating signaling pathway, resulting in Ca(2+) mobilization from intracellular stores and increased intracellular Ca(2+) levels. In addition to this pathway, NPS binding to its receptor activates cAMP/PKA signal transduction. Finally, both pathways converge to activate ERK1/ERK2 phosphorylation and signaling cascade. Inhibits cell growth in response to NPS binding
Protein Sequence
10
MPANLTEGSF
20
HANQTVPMLD
30
SSPVACTEIV
40
TFTEALEAEE
50
WGSFYSSFKT
60
EQLITLWVLF
70
VFTIVGNSVV
80
LFSTWRRKRK
90
SRMTFFVTQL
100
AITDSFTGLI
110
NILTDIIWRF
120
TGDFMAPDLV
130
CRIVRYLQVV
140
LLYASTYVLV
150
SLSIDRYHAI
160
VYPMKFLQGE
170
KQAKVLIGIA
180
WSLSFLFSIP
190
TLIIFGKRTL
200
SNGEVQCWAL
210
WPDDSYWTPY
220
MTIVAFLVYF
230
IPLTIISVIY
240
GLVIRTIWIK
250
SKAHETVISN
260
CSDGELCCSY
270
NRGLISKAKI
280
KAIKYSIVII
290
LAFICCWSPY
300
FLFDMLDNFN
310
LLPDTKERFY
320
ASVIIQNLPA
330
LNSAINPLIY
340
CIFSGSLCSP
350
CKVQRSQDSR
360
MTYRERSERH
370
EMQILSKPEF
I
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0008188 | neuropeptide receptor activity |
| Molecular Function | GO:0005000 | vasopressin receptor activity |
| Biological Process | GO:0007200 | phospholipase C-activating G protein-coupled receptor signaling pathway |
| Biological Process | GO:0141163 | positive regulation of cAMP/PKA signal transduction |
| Biological Process | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.