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Overview

Uniprot IDA0A0H2UHV4
Protein NameEukaryotic translation initiation factor 5B
Gene NameEif5b
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
330 DDKEKEKKKGPSKST
39 EQEPQKGKGKKKKEK

Function

Plays a role in translation initiation. Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after formation of the 80S initiation complex. Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes. In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit

Protein Sequence

10 YGRRQSLVSS 20 TKDDTDLGAL 30 AAEIEGAGAA 40 KEQEPQKGKG 50 KKKKEKKKQD 60 FDENDILREL 70 EELSLEAQGI 80 GADRDAATVK 90 PTENNEEESA 100 SKQDKKKKGQ 110 KGKKTSFDEN 120 DSEELEDKDS 130 KSKKPARPNS 140 EVLLSGSEDA 150 DDPNKLSKKG 160 KKAQKSTKKR 170 DGSEEDEDNS 180 KRSKERSRVN 190 SSGESGGESD 200 EFLQSRKGQK 210 KNQKNKSVPT 220 IDSGNEDDDS 230 SFKIKTVAQK 240 KAEKKERERK 250 KREEEKAKLR 260 KVKEKEELEK 270 GRKEQSKQRE 280 PQKRPDEEVL 290 VLRGTPDAGA 300 ASEEKGDIAA 310 TLEDDNEGDK 320 KKKDKKKKKT 330 EKDDKEKEKK 340 KGPSKSTVKA 350 IQEALAKLRE 360 EEERQKREEE 370 ERIKRLEELE 380 AKRKEEERLE 390 QEKRERKKQK 400 EKERKERLKK 410 EGKLLTKSQR 420 EARARAEVTL 430 RHLQAQGVEV 440 PSKDSLPKKR 450 PVYEDKKKKK 460 TPQQLESKEA 470 LETVEVSAPV 480 EVVDQGVPEK 490 EETPPSVDAE 500 EDEETEDAGL 510 DDWEAMASDE 520 EREKEGNMIH 530 IEVEENPEEE 540 EEEEEDEDEE 550 DSEDEEDEGD 560 SEGSDGDEED 570 YKLSDEKDLG 580 KAGDTKPNKD 590 ASSDSEYDSD 600 DDRTKEERAY 610 DKAKRRIEKR 620 RLEHGKNVNT 630 EKLRAPIICV 640 LGHVDTGKTK 650 ILDKLRHTHV 660 QDGEAGGITQ 670 QIGATNVPLE 680 AINEQTKMIK 690 NFDRENVRIP 700 GMLIIDTPGH 710 ESFSNLRNRG 720 SSLCDIAILV 730 VDIMHGLEPQ 740 TIESINILKS 750 KKCPFIVALN 760 KIDRLYDWKK 770 SPDSDVAVTL 780 KKQKKNTKDE 790 FEERAKAIIV 800 EFAQQGLNAA 810 LFYENKDPRT 820 FVSLVPTSAH 830 TGDGMGSLIY 840 LLVELTQTML 850 SKRLAHCEEL 860 RAQVMEVKAL 870 PGMGTTIDVI 880 LINGRLKEGD 890 TIIVPGVEGP 900 IVTQIRGLLL 910 PPPMKELRVK 920 NQYEKHKEVE 930 AAQGVKILGK 940 DLEKTLAGLP 950 LLVAYKDDEI 960 PVLKDELIHE 970 LKQTLNAIKL 980 EEKGVYVQAS 990 TLGSLEALLE 1000 FLKTSEVPYA 1010 GINIGPVHKK 1020 DVMKASVMLE 1030 HDPQYAVILA 1040 FDVRIERDAQ 1050 EMADSLGVRI 1060 FSAEIIYHLF 1070 DAFTKYRQDY 1080 KKQKQEEFKH 1090 IAVFPCKMKI 1100 LPQYIFNSRD 1110 PIVIGVTVEA 1120 GQVKQGTPMC 1130 VPSKNFVDIG 1140 IVTSIEINHK 1150 QVDVAKKGQE 1160 VCVKIEPIPG 1170 ESPKMFGRHF 1180 EATDILVSKI 1190 SRQSIDALKD 1200 WFRDEMQKSD 1210 WQLIVELKKV FEII

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0003743 translation initiation factor activity

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.