Search Results
Overview
| Uniprot ID | A0A0H2UI21 |
|---|---|
| Protein Name | Carnitine O-acetyltransferase |
| Gene Name | Crat |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 487 | VKGMDDPKVPEQQRV |
Function
Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio. Also plays a crucial role in the transport of fatty acids for beta-oxidation. Responsible for the synthesis of short- and branched-chain acylcarnitines. Active towards some branched-chain amino acid oxidation pathway (BCAAO) intermediates. Trans-2-enoyl-CoAs and 2-methylacyl-CoAs are poor substrates
Protein Sequence
10
MEDEQQREKV
20
KPLGLLKPSS
30
LMKVSGRFKA
40
HQDALPRLPV
50
PPLQQSLDHY
60
LKALQPIVSE
70
EEWAHTKQLV
80
DEFQTSGGVG
90
ERLQKGLERR
100
AKKMENWLSE
110
WWLKTAYLQF
120
RQPVVIYSSP
130
GVLLPKQDFM
140
DLQGQLRFAA
150
KLIEGVLDFK
160
SMIDNETLPV
170
EFLGGQPLCM
180
NQYYQILSSC
190
RVPGLKQDSV
200
VNFLKSKKPP
210
THITVVHNYQ
220
FFELDVYHSD
230
GTPLTSDQIF
240
VQLEKIWNSS
250
LQSNKEPVGI
260
LTSNHRNSWA
270
KAYSSLIKDK
280
VNRESVNSIQ
290
KSIFTVCLDK
300
QVPRVSDDVY
310
RSHVAGQMLH
320
GGGSKFNSGN
330
RWFDKTLQAI
340
YCGRRWLLWM
350
VYEHAAAEGP
360
PIVALVDHVM
370
EYTKKPELVR
380
SPMVPLPMPK
390
KLRFNITPEI
400
KNDIEKAKQN
410
ISIMIQDLDI
420
MMLVFHHFGK
430
DFPKSQKLSP
440
DAFIQIALQL
450
AYYRIYGQAC
460
ATYESASLRM
470
FHLGRTDTIR
480
SASTDSLAFV
490
KGMDDPKVPE
500
QQRVELLRKA
510
VQAHRAYTDR
520
AIRGEAFDRH
530
LLGLKLQAIE
540
DLVSMPDIFM
550
DTSYAIAMHF
560
NLSTSQVPAK
570
TDCVMSFGPV
580
VPDGYGICYN
590
PMEAHINFSV
600
SAYNSCAETN
610
AARMAHYLEK
620
ALLDMRTLLQ
NHPRAKL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0003997 | acyl-CoA oxidase activity |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005777 | peroxisome |
| Molecular Function | GO:0004092 | carnitine O-acetyltransferase activity |
| Molecular Function | GO:0008458 | carnitine O-octanoyltransferase activity |
| Biological Process | GO:0019254 | carnitine metabolic process, CoA-linked |
| Biological Process | GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase |
| Biological Process | GO:0051791 | medium-chain fatty acid metabolic process |
| Biological Process | GO:0046459 | short-chain fatty acid metabolic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.