Search Results
Overview
| Uniprot ID | A0A0J9YUD8 |
|---|---|
| Protein Name | - |
| Gene Name | Hmgb1 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 114 | SEYRPKIKGEHPGLS |
| 82 | MKTYIPPKGETKKKF |
Function
In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation. Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury. In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy. Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages
Protein Sequence
10
MGKGDPKKPR
20
GKMSSYAFFV
30
QTCREEHKKK
40
HPDASVNFSE
50
FSKKCSERWK
60
TMSAKEKGKF
70
EDMAKADKAR
80
YEREMKTYIP
90
PKGETKKKFK
100
DPNAPKRPPS
110
AFFLFCSEYR
120
PKIKGEHPGL
130
SIGDVAKKLG
140
EMWNNTAADD
150
KQPYEKKAAK
160
LKEKYEKVRR
170
MTGYPVLGDY
T
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005694 | chromosome |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0005125 | cytokine activity |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0008201 | heparin binding |
| Molecular Function | GO:0008289 | lipid binding |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0048468 | cell development |
| Biological Process | GO:0071345 | cellular response to cytokine stimulus |
| Biological Process | GO:0006935 | chemotaxis |
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0006954 | inflammatory response |
| Biological Process | GO:0045087 | innate immune response |
| Biological Process | GO:0010508 | positive regulation of autophagy |
| Biological Process | GO:0045597 | positive regulation of cell differentiation |
| Biological Process | GO:0032722 | positive regulation of chemokine production |
| Biological Process | GO:0032728 | positive regulation of interferon-beta production |
| Biological Process | GO:0032732 | positive regulation of interleukin-1 production |
| Biological Process | GO:0032755 | positive regulation of interleukin-6 production |
| Biological Process | GO:0032760 | positive regulation of tumor necrosis factor production |
| Biological Process | GO:0051052 | regulation of DNA metabolic process |
| Biological Process | GO:0032496 | response to lipopolysaccharide |
Reference
[1] Sung E, Sim H, Cho YC, Lee W, Bae JS et al.. Global Profiling of Lysine Acetylation and Lactylation in Kupffer Cells.. J Proteome Res 22(12):3683-3691. 2023 Dec 1. PMID: 37897433.