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Overview

Uniprot IDA0A0K1SB73
Protein NameInner nuclear membrane protein Man1
Gene NameLEMD3
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
864 DGKLVTVKYLRLDRY

Function

Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest

Protein Sequence

10 MAAAAASAPQ 20 QLSDEELFSQ 30 LRRYGLSPGP 40 VTESTRPVYL 50 KKLKKLREEE 60 QQQHRSGGRG 70 TKTRNSNNNN 80 TAAATVAAAG 90 STVAAAGMGV 100 RPVSGDLSYL 110 RTPGGLGRIS 120 TSGPESPLGG 130 TGGASAAPTA 140 GSKVVLGFSS 150 DESDVEASPR 160 DQAGGGGGRK 170 DRAPLQYRGL 180 KPPSAPLTAS 190 EVTNNNSAER 200 RKPHSWWGAR 210 RSAAPELQSP 220 SGRDGAAEDE 230 EQEGEDGEDR 240 DPEAEEPLWS 250 GRTVNGSRLL 260 PYSCRENYSD 270 SEEEDDDDVA 280 SSRQVLKDDS 290 LSRHRLRRGH 300 SKPLSPLPAK 310 SAGGRLETSV 320 QGRGGIAMND 330 RAAAAGSLDR 340 SRNLEEPAAA 350 EQGGGCDPLD 360 SSPIPRYRVN 370 AKKLAPLLPP 380 PLADMDSTLD 390 SSTGSLLKTN 400 NHIGGGAFNV 410 DSPRIFSNSL 420 PPGAAVAASG 430 SLRINHSNHT 440 GSNHTYLKNT 450 YNKPKLSEPE 460 EELLQQFKRE 470 EVSPTGGFSA 480 HYLSMFLLTA 490 ACLFFLILGL 500 TYLGMRGTGV 510 TEDGELTIKN 520 PFDETFGKIQ 530 ESQKNLMMNT 540 LYKLHDRLAQ 550 LAGDHECGSS 560 SQRTLSVQEA 570 AAYLKDLGPE 580 YEDIFNISLQ 590 WIFENGKDVG 600 IRCVGYDPEE 610 ELTDMVDVQF 620 LQSTRPQMSF 630 WCRFRRAFIT 640 VTHRLLLLCL 650 GVVMVCVVLR 660 YMKYRWTKEE 670 EETRQMYDMV 680 VKIIDVLRSH 690 NEACQENKDL 700 QPYMPIPHVR 710 DSLIQPHDRK 720 KMKKVWDRAV 730 DFLAANESRV 740 RTETRRIGGT 750 DFLVWRWIQP 760 SASCDKILVI 770 PSKVWQGQAF 780 HLDRRNSPPN 790 SLTPCLKIRN 800 MFDPVMEIGD 810 QWHLAIQEAI 820 LEKCSDNDGI 830 VHIAVDKNSR 840 EGCVYVKCLS 850 PEYAGKAFKA 860 LHGSWFDGKL 870 VTVKYLRLDR 880 YHHRFPQALT 890 CNTPLKPSNK 900 HMNSMSHLRL 910 RTGLANSQGG S

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005637 nuclear inner membrane
Molecular Function GO:0031490 chromatin DNA binding
Biological Process GO:0032926 negative regulation of activin receptor signaling pathway
Biological Process GO:0030514 negative regulation of BMP signaling pathway
Biological Process GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
Biological Process GO:0006998 nuclear envelope organization

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.