Search Results

Overview

Uniprot IDA0A0S2Z3L2
Protein NameSarcoplasmic/endoplasmic reticulum calcium ATPase 2
Gene NameATP2A2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
995 RNYLEPGKECVQPAT

Function

Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation

Protein Sequence

10 MENAHTKTVE 20 EVLGHFGVNE 30 STGLSLEQVK 40 KLKERWGSNE 50 LPAEEGKTLL 60 ELVIEQFEDL 70 LVRILLLAAC 80 ISFVLAWFEE 90 GEETITAFVE 100 PFVILLILVA 110 NAIVGVWQER 120 NAENAIEALK 130 EYEPEMGKVY 140 RQDRKSVQRI 150 KAKDIVPGDI 160 VEIAVGDKVP 170 ADIRLTSIKS 180 TTLRVDQSIL 190 TGESVSVIKH 200 TDPVPDPRAV 210 NQDKKNMLFS 220 GTNIAAGKAM 230 GVVVATGVNT 240 EIGKIRDEMV 250 ATEQERTPLQ 260 QKLDEFGEQL 270 SKVISLICIA 280 VWIINIGHFN 290 DPVHGGSWIR 300 GAIYYFKIAV 310 ALAVAAIPEG 320 LPAVITTCLA 330 LGTRRMAKKN 340 AIVRSLPSVE 350 TLGCTSVICS 360 DKTGTLTTNQ 370 MSVCRMFILD 380 RVEGDTCSLN 390 EFTITGSTYA 400 PIGEVHKDDK 410 PVNCHQYDGL 420 VELATICALC 430 NDSALDYNEA 440 KGVYEKVGEA 450 TETALTCLVE 460 KMNVFDTELK 470 GLSKIERANA 480 CNSVIKQLMK 490 KEFTLEFSRD 500 RKSMSVYCTP 510 NKPSRTSMSK 520 MFVKGAPEGV 530 IDRCTHIRVG 540 STKVPMTSGV 550 KQKIMSVIRE 560 WGSGSDTLRC 570 LALATHDNPL 580 RREEMHLEDS 590 ANFIKYETNL 600 TFVGCVGMLD 610 PPRIEVASSV 620 KLCRQAGIRV 630 IMITGDNKGT 640 AVAICRRIGI 650 FGQDEDVTSK 660 AFTGREFDEL 670 NPSAQRDACL 680 NARCFARVEP 690 SHKSKIVEFL 700 QSFDEITAMT 710 GDGVNDAPAL 720 KKAEIGIAMG 730 SGTAVAKTAS 740 EMVLADDNFS 750 TIVAAVEEGR 760 AIYNNMKQFI 770 RYLISSNVGE 780 VVCIFLTAAL 790 GFPEALIPVQ 800 LLWVNLVTDG 810 LPATALGFNP 820 PDLDIMNKPP 830 RNPKEPLISG 840 WLFFRYLAIG 850 CYVGAATVGA 860 AAWWFIAADG 870 GPRVSFYQLS 880 HFLQCKEDNP 890 DFEGVDCAIF 900 ESPYPMTMAL 910 SVLVTIEMCN 920 ALNSLSENQS 930 LLRMPPWENI 940 WLVGSICLSM 950 SLHFLILYVE 960 PLPLIFQITP 970 LNVTQWLMVL 980 KISLPVILMD 990 ETLKFVARNY 1000 LEPGKECVQP 1010 ATKSCSFSAC 1020 TDGISWPFVL 1030 LIMPLVIWVY 1040 STDTNFSDMF WS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0031095 platelet dense tubular network membrane
Biological Process GO:0006937 regulation of muscle contraction
Cellular Component GO:0097470 ribbon synapse
Cellular Component GO:0033017 sarcoplasmic reticulum membrane
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0106222 lncRNA binding
Molecular Function GO:0005388 P-type calcium transporter activity
Biological Process GO:1990036 calcium ion import into sarcoplasmic reticulum
Biological Process GO:0006874 intracellular calcium ion homeostasis
Biological Process GO:0003012 muscle system process
Biological Process GO:1903779 regulation of cardiac conduction

Reference

PMID: N/A