Search Results
Overview
| Uniprot ID | A0A0S2Z3W7 |
|---|---|
| Protein Name | XTP/dITP diphosphatase |
| Gene Name | ITPA |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 110 | LLAGFEDKSAYALCT |
| 30 | VVQILGDKFPCTLVA |
Function
Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions
Protein Sequence
10
MAASLVGKKI
20
VFVTGNAKKL
30
EEVVQILGDK
40
FPCTLVAQKI
50
DLPEYQGEPD
60
EISIQKCQEA
70
VRQVQGPVLV
80
EDTCLCFNAL
90
GGLPGPYIKW
100
FLEKLKPEGL
110
HQLLAGFEDK
120
SAYALCTFAL
130
STGDPSQPVR
140
LFRGRTSGRI
150
VAPRGCQDFG
160
WDPCFQPDGY
170
EQTYAEMPKA
180
EKNAVSHRFR
190
ALLELQEYFG
SLAA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0035870 | dITP diphosphatase activity |
| Molecular Function | GO:0036220 | ITP diphosphatase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0000166 | nucleotide binding |
| Biological Process | GO:0009143 | nucleoside triphosphate catabolic process |
| Biological Process | GO:0009117 | nucleotide metabolic process |
Reference
PMID: N/A