Search Results
Overview
| Uniprot ID | A0A0S2Z4J1 |
|---|---|
| Protein Name | Peroxisomal multifunctional enzyme type 2 |
| Gene Name | HSD17B4 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 284 | CDFENASKPQSIQES |
| 528 | ASLAGFDKPILHGLC |
Function
Bifunctional enzyme acting on the peroxisomal fatty acid beta-oxidation pathway. Catalyzes two of the four reactions in fatty acid degradation: hydration of 2-enoyl-CoA (trans-2-enoyl-CoA) to produce (3R)-3-hydroxyacyl-CoA, and dehydrogenation of (3R)-3-hydroxyacyl-CoA to produce 3-ketoacyl-CoA (3-oxoacyl-CoA), which is further metabolized by SCPx. Can use straight-chain and branched-chain fatty acids, as well as bile acid intermediates as substrates
Protein Sequence
10
MGSPLRFDGR
20
VVLVTGAGAG
30
LGRAYALAFA
40
ERGALVVVND
50
LGGDFKGVGK
60
GSLAADKVVE
70
EIRRRGGKAV
80
ANYDSVEEGE
90
KVVKTALDAF
100
GRIDVVVNNA
110
GILRDRSFAR
120
ISDEDWDIIH
130
RVHLRGSFQV
140
TRAAWEHMKK
150
QKYGRIIMTS
160
SASGIYGNFG
170
QANYSAAKLG
180
LLGLANSLAI
190
EGRKSNIHCN
200
TIAPNAGSRM
210
TQTVMPEDLV
220
EALKPEYVAP
230
LVLWLCHESC
240
EENGGLFEVG
250
AGWIGKLRWE
260
RTLGAIVRQK
270
NHPMTPEAVK
280
ANWKKICDFE
290
NASKPQSIQE
300
STGSIIEVLS
310
KIDSEGGVSA
320
NHTSRATSTA
330
TSGFAGAIGQ
340
KLPPFSYAYT
350
ELEAIMYALG
360
VGASIKDPKD
370
LKFIYEGSSD
380
FSCLPTFGVI
390
IGQKSMMGGG
400
LAEIPGLSIN
410
FAKVLHGEQY
420
LELYKPLPRA
430
GKLKCEAVVA
440
DVLDKGSGVV
450
IIMDVYSYSE
460
KELICHNQFS
470
LFLVGSGGFG
480
GKRTSDKVKV
490
AVAIPNRPPD
500
AVLTDTTSLN
510
QAALYRLSGD
520
WNPLHIDPNF
530
ASLAGFDKPI
540
LHGLCTFGFS
550
ARRVLQQFAD
560
NDVSRFKAIK
570
ARFAKPVYPG
580
QTLQTEMWKE
590
GNRIHFQTKV
600
QETGDIVISN
610
AYVDLAPTSG
620
TSAKTPSEGG
630
KLQSTFVFEE
640
IGRRLKDIGP
650
EVVKKVNAVF
660
EWHITKGGNI
670
GAKWTIDLKS
680
GSGKVYQGPA
690
KGAADTTIIL
700
SDEDFMEVVL
710
GKLDPQKAFF
720
SGRLKARGNI
730
MLSQKLQMIL
KDYAKL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase |
| Cellular Component | GO:0005782 | peroxisomal matrix |
| Cellular Component | GO:0005777 | peroxisome |
| Molecular Function | GO:0080023 | (2E)-enoyl-CoA hydratase activity |
| Molecular Function | GO:0003857 | (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity |
| Molecular Function | GO:0033989 | 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity |
| Molecular Function | GO:0016853 | isomerase activity |
| Biological Process | GO:0006633 | fatty acid biosynthetic process |
Reference
PMID: N/A