Search Results
Overview
| Uniprot ID | A0A0S2Z4R1 |
|---|---|
| Protein Name | Tyrosine--tRNA ligase |
| Gene Name | YARS |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 412 | GLVQFVPKEELQDRL |
Function
Tyrosine--tRNA ligase that catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). Also acts as a positive regulator of poly-ADP-ribosylation in the nucleus, independently of its tyrosine--tRNA ligase activity. Activity is switched upon resveratrol-binding: resveratrol strongly inhibits the tyrosine--tRNA ligase activity and promotes relocalization to the nucleus, where YARS1 specifically stimulates the poly-ADP-ribosyltransferase activity of PARP1
Protein Sequence
10
MGDAPSPEEK
20
LHLITRNLQE
30
VLGEEKLKEI
40
LKERELKIYW
50
GTATTGKPHV
60
AYFVPMSKIA
70
DFLKAGCEVT
80
ILFADLHAYL
90
DNMKAPWELL
100
ELRVSYYENV
110
IKAMLESIGV
120
PLEKLKFIKG
130
TDYQLSKEYT
140
LDVYRLSSVV
150
TQHDSKKAGA
160
EVVKQVEHPL
170
LSGLLYPGLQ
180
ALDEEYLKVD
190
AQFGGIDQRK
200
IFTFAEKYLP
210
ALGYSKRVHL
220
MNPMVPGLTG
230
SKMSSSEEES
240
KIDLLDRKED
250
VKKKLKKAFC
260
EPGNVENNGV
270
LSFIKHVLFP
280
LKSEFVILRD
290
EKWGGNKTYT
300
AYVDLEKDFA
310
AEVVHPGDLK
320
NSVEVALNKL
330
LDPIREKFNT
340
PALKKLASAA
350
YPDPSKQKPM
360
AKGPAKNSEP
370
EEVIPSRLDI
380
RVGKIITVEK
390
HPDADSLYVE
400
KIDVGEAEPR
410
TVVSGLVQFV
420
PKEELQDRLV
430
VVLCNLKPQK
440
MRGVESQGML
450
LCASIEGINR
460
QVEPLDPPAG
470
SAPGEHVFVK
480
GYEKGQPDEE
490
LKPKKKVFEK
500
LQADFKISEE
510
CIAQWKQTNF
520
MTKLGSISCK
SLKGGNIS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0016604 | nuclear body |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0000049 | tRNA binding |
| Molecular Function | GO:0004831 | tyrosine-tRNA ligase activity |
| Biological Process | GO:0006950 | response to stress |
| Biological Process | GO:0006437 | tyrosyl-tRNA aminoacylation |
Reference
PMID: N/A