Overview
| Uniprot ID | A0A140TA89 |
|---|
| Protein Name | Glycine amidinotransferase |
|---|
| Gene Name | Gatm |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 424 |
PIQKMFEKLGISTIK |
Function
Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives. Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain
Protein Sequence
10
MGRALGAATK
20
AARAAAGWEL
30
ARAWRLGPCA
40
HRAAAETGAM
50
LRVRCLRGGS
60
RGAEAVHYIG
70
SRLGGSLTGW
80
VQRTFQSTQA
90
ATASSQNSCA
100
AEDKATHPLP
110
KDCPVSSYNE
120
WDPLEEVIVG
130
RAENACVPPF
140
TVEVKANTYE
150
KYWPFYQKNG
160
GLYFPKDHLK
170
KAVAEVEEMC
180
NILSMEGVTV
190
KRPDPIDWSL
200
KYKTPDFEST
210
GLYSAMPRDI
220
LMVVGNEIIE
230
APMAWRSRFF
240
EYRAYRSIIK
250
DYFHRGAKWT
260
TAPKPTMADE
270
LYDQDYPIHS
280
VEDRHKLAAQ
290
GKFVTTEFEP
300
CFDAADFIRA
310
GRDIFAQRSQ
320
VTNYLGIEWM
330
RRHLAPDYRV
340
HIISFKDPNP
350
MHIDATFNII
360
GPGLVLSNPD
370
RPCHQIDLFK
380
KAGWTIVTPP
390
TPVIPDDHPL
400
WMSSKWLSMN
410
VLMLDEKRVM
420
VDANEVPIQK
430
MFEKLGISTI
440
KVNIRNANSL
450
GGGFHCWTCD
460
VRRRGTLQSY
FD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0005758 |
mitochondrial intermembrane space |
| Molecular Function |
GO:0015068 |
glycine amidinotransferase activity |
| Biological Process |
GO:0006601 |
creatine biosynthetic process |
| Biological Process |
GO:0007611 |
learning or memory |
| Biological Process |
GO:0014889 |
muscle atrophy |
| Biological Process |
GO:0120162 |
positive regulation of cold-induced thermogenesis |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.