Search Results
Overview
| Uniprot ID | A0A140TA95 |
|---|---|
| Protein Name | Myosin phosphatase Rho-interacting protein |
| Gene Name | Mprip |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 161 | QNQKKKRKVEPPTPQ |
| 206 | AEKVPTTKSTLWQEE |
| 278 | SGYFSLEKAKQDLRA |
| 508 | RRREGRSKTFDWAEF |
Function
Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells
Protein Sequence
10
MSAAKENPCR
20
KFQANIFNKS
30
KCQNCFKPRE
40
SHLLNDEDLT
50
QAKPIYGGWL
60
LLAPDGTDFD
70
NPVHRSRKWQ
80
RRFFILYEHG
90
LLRYALDEMP
100
TTLPQGTINM
110
NQCTDVVDGE
120
ARTGQKFSLC
130
ILTPDKEHFI
140
RAETKEIISG
150
WLEMLMVYPR
160
TNKQNQKKKR
170
KVEPPTPQEP
180
GPAKMAVTSS
190
SGGSSGSSSS
200
SSSSSIPSAE
210
KVPTTKSTLW
220
QEEMRAKDQP
230
DGTSLSPVQS
240
PSQSQPPAAC
250
TPRETGLDSK
260
EDENILSGDR
270
VDGGRKVRVE
280
SGYFSLEKAK
290
QDLRAEEQLP
300
PLLSPPSPST
310
PHSRRSQVIE
320
KFEALDIEKA
330
EHMETNMLIL
340
TTPSSDTRQG
350
RSERRAIPRK
360
RPDLLNFKKG
370
WLTKQYEDGQ
380
WKKHWFVLAD
390
QSLRYYRDSV
400
AEEAADLDGE
410
INLSTCYDVT
420
EYPVQRNYGF
430
QIHTKEGEFT
440
LSAMTSGIRR
450
NWIQTIMKHV
460
LPTSAPDVTS
470
SLPEGKNKST
480
SFDTCLRPSE
490
KQEAEPGEPD
500
PEQKKSRARE
510
RRREGRSKTF
520
DWAEFRPIQQ
530
ALAQERASTV
540
GSSDSGDPGC
550
LEAEPGELER
560
ERARRREERR
570
KRFGMLDTND
580
GPGMEDTALR
590
MDIDRSPGLL
600
GTPDLKTQNV
610
HVEIEQRWHQ
620
VETTPLREEK
630
QVPIAPLHLS
640
LEDRSERLST
650
HELTSLLEKE
660
LEQSQKEASD
670
LLEQNRLLQD
680
QLRVALGREQ
690
SAREGYVLQT
700
EVATSPSGAW
710
QRLHRVNQDL
720
QSELEAQCRR
730
QELITQQIQT
740
LKHSYGEAKD
750
AIRHHEAEIQ
760
TLQTRLGDAA
770
AELAIKEQAL
780
AKLKGELKLE
790
QGKVREQLEE
800
WQHSKAVLRG
810
QLRASEQKLQ
820
STEALLLEKT
830
QELRDLETKQ
840
ALQRDRQKEV
850
QRLQECIAEL
860
SQQLGTSEQA
870
QRLMEKKLKR
880
NYTLLLESCE
890
QEKQALLQNL
900
KEVEDKASAY
910
EDQLQGHVQQ
920
VEALQKEKLS
930
ETCKGTERVH
940
KLQEELEARE
950
ASIRQLAQHV
960
QSLHDERDLI
970
KHQFQELMER
980
VATSDGDVAE
990
LQEKLKGREA
1000
DYQNLEHSHH
1010
RVSIQLQSVR
1020
TLLREKEEEL
1030
KLIKEAHERV
1040
LEKKDQDLNE
1050
ALVKMIALGS
1060
SLEETEIKLQ
1070
EKEECLRRFV
1080
SDSPKDAKEP
1090
QSTTDPTEED
1100
SGILTLGSVT
1110
RVFPGFPHSQ
1120
PEDEDPSASL
1130
GEEGSSGSLS
1140
REENIIPPKS
1150
ADMPDREGQL
1160
QSTVKSDQGA
1170
PVKRPRIRFS
1180
TIQCQRYIHP
1190
EGCAKAWTSS
1200
TSSDTSQDQS
1210
PSEDSVSSEA
1220
TPSTLPAAAD
1230
AETYISIIHS
1240
LETKLYVTEE
1250
KLKDVTVRLE
1260
SQQGQSQEAL
1270
LALHQQWAGT
1280
EAQLREQLRV
1290
SLLQASTLAS
1300
QLEQERQQKV
1310
TNIEHHSGEL
1320
EDFQAKNSQA
1330
LTCLENCWEK
1340
LRSLPQANQE
1350
EGQDACAASL
1360
ANIESMLVSA
1370
IKALQPWASP
1380
AESRMQAEKE
1390
KGHPMESGIA
1400
APMQQPCQPI
1410
LNEQEHRKLL
1420
SAQIVLEASL
1430
INQIADSLKS
1440
TTSNVYGVLC
1450
ELTQSGEWPL
1460
KKESAAPSAG
1470
APMEIWAKKV
1480
LVNGEFWSQV
1490
ESLSKHLGTL
1500
GEETACTSAD
1510
KQQHVPQSLA
1520
DATWIRAELS
1530
YATQSVRELF
1540
HHRLQSIQET
1550
LQGTQAALQQ
1560
HKCMLGEILG
1570
AYQTPDFERV
1580
IQQILETLRH
1590
PTDREDHVQT
1600
SWDQSPLGEV
1610
LRPGTDGSQE
1620
PLQAFHQSPE
1630
VLAAIQDELA
1640
QQLREKASIL
1650
EEISAALPVL
1660
PPTEPLGGCQ
1670
RLLQMSQHLS
1680
YDACLEGLGQ
1690
YSSLLVQDAI
1700
IQAQVCYAAC
1710
RIRLEYEKEL
1720
QFYKKACQEA
1730
RGASCQKRTQ
1740
AVGALKEEYE
1750
ELLHKQKSEY
1760
QKVITLIEKE
1770
NTELKAKVSQ
1780
LDHQQRCLQE
1790
AESKHSESMF
1800
ALQGRYEEEI
1810
RCMVEQLSHT
1820
ENTLQAERSR
1830
VLSQLDASVK
1840
DRQAMEQHHV
1850
QQMKMLEDRF
1860
QLKVRELQAV
1870
HQEELRALQE
1880
HYIWSMRGAL
1890
SLCQPSHPDS
1900
PLAPGPSEPR
1910
AVPAAKDEAE
1920
SMTGLRERIQ
1930
ELEAQMGVMR
1940
EELGHKELEG
1950
DVAALQEKYQ
1960
RDFESLKATC
1970
ERGFAAMEET
1980
HQKKIEDLQR
1990
QHQRELEKLR
2000
EEKDRLLAEE
2010
TAATISAIEA
2020
MKNAHREEME
2030
RELEKSQRSQ
2040
ISSINSDIEA
2050
LRRQYLEELQ
2060
SVQRELEVLS
2070
EQYSQKCLEN
2080
AHLAQALEAE
2090
RQALRQCQRE
2100
NQELNAHNQE
2110
LNNRLAAEIT
2120
RLRTLLTGEG
2130
GGESTGLPLT
2140
QGKDAYELEV
2150
LLRVKESEIQ
2160
YLKQEISSLK
2170
DELQTALRDK
2180
KYASDKYKDI
2190
YTELSIAKAK
2200
ADCDISRLKE
2210
QLKAATEALG
2220
EKSPEGTTVS
2230
GYDIMKSKSN
2240
PDFLKKDRSC
2250
VTRQLRNIRS
2260
KSLKEGLTVQ
2270
ERLKLFESRD
LKKD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Molecular Function | GO:0003779 | actin binding |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.