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Overview

Uniprot IDA0A140TA95
Protein NameMyosin phosphatase Rho-interacting protein
Gene NameMprip
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
161 QNQKKKRKVEPPTPQ
206 AEKVPTTKSTLWQEE
278 SGYFSLEKAKQDLRA
508 RRREGRSKTFDWAEF

Function

Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells

Protein Sequence

10 MSAAKENPCR 20 KFQANIFNKS 30 KCQNCFKPRE 40 SHLLNDEDLT 50 QAKPIYGGWL 60 LLAPDGTDFD 70 NPVHRSRKWQ 80 RRFFILYEHG 90 LLRYALDEMP 100 TTLPQGTINM 110 NQCTDVVDGE 120 ARTGQKFSLC 130 ILTPDKEHFI 140 RAETKEIISG 150 WLEMLMVYPR 160 TNKQNQKKKR 170 KVEPPTPQEP 180 GPAKMAVTSS 190 SGGSSGSSSS 200 SSSSSIPSAE 210 KVPTTKSTLW 220 QEEMRAKDQP 230 DGTSLSPVQS 240 PSQSQPPAAC 250 TPRETGLDSK 260 EDENILSGDR 270 VDGGRKVRVE 280 SGYFSLEKAK 290 QDLRAEEQLP 300 PLLSPPSPST 310 PHSRRSQVIE 320 KFEALDIEKA 330 EHMETNMLIL 340 TTPSSDTRQG 350 RSERRAIPRK 360 RPDLLNFKKG 370 WLTKQYEDGQ 380 WKKHWFVLAD 390 QSLRYYRDSV 400 AEEAADLDGE 410 INLSTCYDVT 420 EYPVQRNYGF 430 QIHTKEGEFT 440 LSAMTSGIRR 450 NWIQTIMKHV 460 LPTSAPDVTS 470 SLPEGKNKST 480 SFDTCLRPSE 490 KQEAEPGEPD 500 PEQKKSRARE 510 RRREGRSKTF 520 DWAEFRPIQQ 530 ALAQERASTV 540 GSSDSGDPGC 550 LEAEPGELER 560 ERARRREERR 570 KRFGMLDTND 580 GPGMEDTALR 590 MDIDRSPGLL 600 GTPDLKTQNV 610 HVEIEQRWHQ 620 VETTPLREEK 630 QVPIAPLHLS 640 LEDRSERLST 650 HELTSLLEKE 660 LEQSQKEASD 670 LLEQNRLLQD 680 QLRVALGREQ 690 SAREGYVLQT 700 EVATSPSGAW 710 QRLHRVNQDL 720 QSELEAQCRR 730 QELITQQIQT 740 LKHSYGEAKD 750 AIRHHEAEIQ 760 TLQTRLGDAA 770 AELAIKEQAL 780 AKLKGELKLE 790 QGKVREQLEE 800 WQHSKAVLRG 810 QLRASEQKLQ 820 STEALLLEKT 830 QELRDLETKQ 840 ALQRDRQKEV 850 QRLQECIAEL 860 SQQLGTSEQA 870 QRLMEKKLKR 880 NYTLLLESCE 890 QEKQALLQNL 900 KEVEDKASAY 910 EDQLQGHVQQ 920 VEALQKEKLS 930 ETCKGTERVH 940 KLQEELEARE 950 ASIRQLAQHV 960 QSLHDERDLI 970 KHQFQELMER 980 VATSDGDVAE 990 LQEKLKGREA 1000 DYQNLEHSHH 1010 RVSIQLQSVR 1020 TLLREKEEEL 1030 KLIKEAHERV 1040 LEKKDQDLNE 1050 ALVKMIALGS 1060 SLEETEIKLQ 1070 EKEECLRRFV 1080 SDSPKDAKEP 1090 QSTTDPTEED 1100 SGILTLGSVT 1110 RVFPGFPHSQ 1120 PEDEDPSASL 1130 GEEGSSGSLS 1140 REENIIPPKS 1150 ADMPDREGQL 1160 QSTVKSDQGA 1170 PVKRPRIRFS 1180 TIQCQRYIHP 1190 EGCAKAWTSS 1200 TSSDTSQDQS 1210 PSEDSVSSEA 1220 TPSTLPAAAD 1230 AETYISIIHS 1240 LETKLYVTEE 1250 KLKDVTVRLE 1260 SQQGQSQEAL 1270 LALHQQWAGT 1280 EAQLREQLRV 1290 SLLQASTLAS 1300 QLEQERQQKV 1310 TNIEHHSGEL 1320 EDFQAKNSQA 1330 LTCLENCWEK 1340 LRSLPQANQE 1350 EGQDACAASL 1360 ANIESMLVSA 1370 IKALQPWASP 1380 AESRMQAEKE 1390 KGHPMESGIA 1400 APMQQPCQPI 1410 LNEQEHRKLL 1420 SAQIVLEASL 1430 INQIADSLKS 1440 TTSNVYGVLC 1450 ELTQSGEWPL 1460 KKESAAPSAG 1470 APMEIWAKKV 1480 LVNGEFWSQV 1490 ESLSKHLGTL 1500 GEETACTSAD 1510 KQQHVPQSLA 1520 DATWIRAELS 1530 YATQSVRELF 1540 HHRLQSIQET 1550 LQGTQAALQQ 1560 HKCMLGEILG 1570 AYQTPDFERV 1580 IQQILETLRH 1590 PTDREDHVQT 1600 SWDQSPLGEV 1610 LRPGTDGSQE 1620 PLQAFHQSPE 1630 VLAAIQDELA 1640 QQLREKASIL 1650 EEISAALPVL 1660 PPTEPLGGCQ 1670 RLLQMSQHLS 1680 YDACLEGLGQ 1690 YSSLLVQDAI 1700 IQAQVCYAAC 1710 RIRLEYEKEL 1720 QFYKKACQEA 1730 RGASCQKRTQ 1740 AVGALKEEYE 1750 ELLHKQKSEY 1760 QKVITLIEKE 1770 NTELKAKVSQ 1780 LDHQQRCLQE 1790 AESKHSESMF 1800 ALQGRYEEEI 1810 RCMVEQLSHT 1820 ENTLQAERSR 1830 VLSQLDASVK 1840 DRQAMEQHHV 1850 QQMKMLEDRF 1860 QLKVRELQAV 1870 HQEELRALQE 1880 HYIWSMRGAL 1890 SLCQPSHPDS 1900 PLAPGPSEPR 1910 AVPAAKDEAE 1920 SMTGLRERIQ 1930 ELEAQMGVMR 1940 EELGHKELEG 1950 DVAALQEKYQ 1960 RDFESLKATC 1970 ERGFAAMEET 1980 HQKKIEDLQR 1990 QHQRELEKLR 2000 EEKDRLLAEE 2010 TAATISAIEA 2020 MKNAHREEME 2030 RELEKSQRSQ 2040 ISSINSDIEA 2050 LRRQYLEELQ 2060 SVQRELEVLS 2070 EQYSQKCLEN 2080 AHLAQALEAE 2090 RQALRQCQRE 2100 NQELNAHNQE 2110 LNNRLAAEIT 2120 RLRTLLTGEG 2130 GGESTGLPLT 2140 QGKDAYELEV 2150 LLRVKESEIQ 2160 YLKQEISSLK 2170 DELQTALRDK 2180 KYASDKYKDI 2190 YTELSIAKAK 2200 ADCDISRLKE 2210 QLKAATEALG 2220 EKSPEGTTVS 2230 GYDIMKSKSN 2240 PDFLKKDRSC 2250 VTRQLRNIRS 2260 KSLKEGLTVQ 2270 ERLKLFESRD LKKD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Molecular Function GO:0003779 actin binding

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.