Search Results
Overview
| Uniprot ID | A0A140TAB4 |
|---|---|
| Protein Name | Core histone macro-H2A |
| Gene Name | Macroh2a1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 123 | KKRGSKGKLEAIITP |
| 134 | IITPPPAKKAKSPSQ |
| 142 | KAKSPSQKKPVAKKT |
Function
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes
Protein Sequence
10
MSSRGGKKKS
20
TKTSRSAKAG
30
VIFPVGRMLR
40
YIKKGHPKYR
50
IGVGAPVYMA
60
AVLEYLTAEI
70
LELAGNAARD
80
NKKGRVTPRH
90
ILLAVANDEE
100
LNQLLKGVTI
110
ASGGVLPNIH
120
PELLAKKRGS
130
KGKLEAIITP
140
PPAKKAKSPS
150
QKKPVAKKTG
160
GKKGARKSKK
170
KQGEVSKAAS
180
ADSTTEGAPT
190
DGFTVLSTKS
200
LFLGQKLQVV
210
QADIASIDSD
220
AVVHPTNTDF
230
YIGGEVGSTL
240
EKKGGKEFVE
250
AVLELRKKNG
260
PLEVAGAAVS
270
AGHGLPAKFV
280
IHCNSPVWGA
290
DKCEELLEKT
300
VKNCLALADD
310
RKLKSIAFPS
320
IGSGRNGFPK
330
QTAAQLILKA
340
ISSYFVSTMS
350
SSIKTVYFVL
360
FDSESIGIYV
QEMAKLDAN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000786 | nucleosome |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0031490 | chromatin DNA binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0030527 | structural constituent of chromatin |
| Biological Process | GO:0006334 | nucleosome assembly |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.