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Overview

Uniprot IDA0A140TAH1
Protein NameHepatocyte growth factor-regulated tyrosine kinase substrate
Gene NameHgs
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
581 LEIMRQKKQEYLEVQ

Function

Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation

Protein Sequence

10 MSGPMDAQSP 20 CASARLVSEQ 30 DSGRRGDIAR 40 ARAEKERRKR 50 KLGGASAPKE 60 GAPAASVRSG 70 VAMGRGSGTF 80 ERLLDKATSQ 90 LLLETDWESI 100 LQICDLIRQG 110 DTQAKYAVNS 120 IKKKVNDKNP 130 HVALYALEVM 140 ESVVKNCGQT 150 VHDEVANKQT 160 MEELKELLKR 170 QVEVNVRNKI 180 LYLIQAWAHA 190 FRNEPKYKVV 200 QDTYQIMKVE 210 GHVFPEFKES 220 DAMFAAERAP 230 DWVDAEECHR 240 CRVQFGVVTR 250 KHHCRACGQI 260 FCGKCSSKYS 270 TIPKFGIEKE 280 VRVCEPCYEQ 290 LNKKAEGKAA 300 STTELPPEYL 310 TSPLSQQSQL 320 PPKRDETALQ 330 EEEELQLALA 340 LSQSEAEEKE 350 RMRQKSTYTA 360 HPKSEPAPLA 370 SSAPPAGSLY 380 SSPVNSSAPL 390 AEDIDPELAR 400 YLNRNYWEKK 410 QEEARKSPTP 420 SAPVPLTEPA 430 AQPGEGHTAP 440 NSMVEAPLPE 450 TDSQPITSCS 460 GPFSEYQNGE 470 SEESHEQFLK 480 ALQNAVSTFV 490 NRMKSNHMRG 500 RSITNDSAVL 510 SLFQSINSTH 520 PQLLELLNRL 530 DERRLYYEGL 540 QDKLAQIRDA 550 RGALSALREE 560 HREKLRRAAE 570 EAERQRQIQL 580 AQKLEIMRQK 590 KQEYLEVQRQ 600 LAIQRLQEQE 610 KERQMRLEQQ 620 KQTVQMRAQM 630 PAFPLPYAQQ 640 AMPTAGGVLY 650 QPSGPTSFPG 660 TFSPAGSVEG 670 SPMHGVYMSQ 680 PAPATGPYPS 690 MPGTTADPSM 700 VSAYMYPAGA 710 PGAQAAPQAQ 720 AGPTTNPAYS 730 SYQPTPTPGY 740 QNVASQAPQS 750 LPAISQPPQT 760 SNIGYMGSQP 770 MSMGYQPYNM 780 QNLMTTLPGQ 790 DASLPAQQPY 800 ITGQQPMYQQ 810 MAPSTGPPQQ 820 QPPVAQPPPT 830 QGPPAQGNET QLISFD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Biological Process GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway
Biological Process GO:1903543 positive regulation of exosomal secretion
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0072657 protein localization to membrane
Biological Process GO:0006622 protein targeting to lysosome
Cellular Component GO:0031901 early endosome membrane
Cellular Component GO:0033565 ESCRT-0 complex
Cellular Component GO:0032585 multivesicular body membrane
Molecular Function GO:0035091 phosphatidylinositol binding
Molecular Function GO:0019904 protein domain specific binding
Molecular Function GO:0043130 ubiquitin binding
Molecular Function GO:0044389 ubiquitin-like protein ligase binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0010324 membrane invagination
Biological Process GO:0016525 negative regulation of angiogenesis
Biological Process GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway
Biological Process GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.