Overview
| Uniprot ID | A0A140TAH5 |
|---|
| Protein Name | AP-2 complex subunit mu |
|---|
| Gene Name | Ap2m1 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 222 |
NDKIVIEKQGKGTAD |
| 254 |
HQCVRLSKFDSERSI |
| 310 |
VVIKSNFKPSLLAQK |
| 343 |
MKGKAKYKASENAIV |
| 403 |
GLKVRYLKVFEPKLN |
| 408 |
YLKVFEPKLNYSDHD |
| 59 |
RTSFFHVKRSNIWLA |
Function
Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules
Protein Sequence
10
MIGGLFIYNH
20
KGEVLISRVY
30
RDDIGRNAVD
40
AFRVNVIHAR
50
QQVRSPVTNI
60
ARTSFFHVKR
70
SNIWLAAVTK
80
QNVNAAMVFE
90
FLYKMCDVMA
100
AYFGKISEEN
110
IKNNFVLIYE
120
LLDEILDFGY
130
PQNSETGALK
140
TFITQQGIKS
150
QTKEEQSQIT
160
SQVTGQIGWR
170
REGIKYRRNE
180
LFLDVLESVN
190
LLMSPQGQVL
200
SAHVSGRVVM
210
KSYLSGMPEC
220
KFGMNDKIVI
230
EKQGKGTADE
240
TSKSGKQSIA
250
IDDCTFHQCV
260
RLSKFDSERS
270
ISFIPPDGEF
280
ELMRYRTTKD
290
IILPFRVIPL
300
VREVGRTKLE
310
VKVVIKSNFK
320
PSLLAQKIEV
330
RIPTPLNTSG
340
VQVICMKGKA
350
KYKASENAIV
360
WKIKRMAGMK
370
ESQISAEIEL
380
LPTNDKKKWA
390
RPPISMNFEV
400
PFAPSGLKVR
410
YLKVFEPKLN
420
YSDHDVIKWV
430
RYIGRSGIYE
TRC
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0030122 |
AP-2 adaptor complex |
| Cellular Component |
GO:0098978 |
glutamatergic synapse |
| Cellular Component |
GO:0098794 |
postsynapse |
| Cellular Component |
GO:0098793 |
presynapse |
| Molecular Function |
GO:0097718 |
disordered domain specific binding |
| Molecular Function |
GO:0008289 |
lipid binding |
| Molecular Function |
GO:0005048 |
signal sequence binding |
| Molecular Function |
GO:0044325 |
transmembrane transporter binding |
| Biological Process |
GO:0072583 |
clathrin-dependent endocytosis |
| Biological Process |
GO:0006886 |
intracellular protein transport |
| Biological Process |
GO:1903077 |
negative regulation of protein localization to plasma membrane |
| Biological Process |
GO:0098884 |
postsynaptic neurotransmitter receptor internalization |
| Biological Process |
GO:0097494 |
regulation of vesicle size |
| Biological Process |
GO:0048488 |
synaptic vesicle endocytosis |
| Biological Process |
GO:0006900 |
vesicle budding from membrane |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.