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Overview

Uniprot ID	A0A140TAJ3
Protein Name	Far upstream element-binding protein 1
Gene Name	Fubp1
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
389	KTGLIIGKGGETIKS

Function

Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription

Protein Sequence

10 MADYSTVPPP 20 SSGSAGGGGG 30 GGVNDAFKDA 40 LQRARQIAAK 50 IGGDAGTSLN 60 SNDYGYGGQK 70 RPLEDGDQPD 80 AKKVPPQNDS 90 FGAQLPPMHQ 100 QQRSVMTEEY 110 KVPDGMVGFI 120 IGRGGEQISR 130 IQQESGCKIQ 140 IAPDSGGLPE 150 RSCMLTGTPE 160 SVQSAKRLLD 170 QIVEKGRPAP 180 GFHHGDGPGN 190 AVQEIMIPAS 200 KAGLVIGKGG 210 ETIKQLQERA 220 GVKMVMIQDG 230 PQNTGADKPL 240 RITGDPYKVQ 250 QAKEMVLELI 260 RDQGGFREVR 270 NEYGSRIGGN 280 EGIDVPIPRF 290 AVGIVIGRNG 300 EMIKKIQNDA 310 GVRIQFKPDD 320 GTTPDRIAQI 330 TGPPDRCQHA 340 AEIITDLLRS 350 VQAGNPGGPG 360 PGGRGRGRGQ 370 GNWNMGPPGG 380 LQEFNFIVPT 390 GKTGLIIGKG 400 GETIKSISQQ 410 SGARIELQRN 420 PPPNADPNMK 430 LFTIRGTPQQ 440 IDYARQLIEE 450 KIGGPVNPLG 460 PPVPHGPHGV 470 PGPHGPPGPP 480 GPGTPMGPYN 490 PAPYNPGPPG 500 PAPHGPPAPY 510 APQGWGNAYP 520 HWQQQAPPDP 530 AKAGTDPNSA 540 AWAAYYAHYY 550 QQQAQPPPAA 560 PAGAPTTTQT 570 NGQGNYGDQQ 580 NPAPAGQVDY 590 TKAWEEYYKK 600 MGQAVPAPAG 610 APPGGQPDYS 620 AAWAEYYRQQ 630 AAYYAQTSPQ 640 GMPQHPPAPQ 650 CLPRPSTLGS 660 AAKSNRNYPC VNRRLA

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:0006355	regulation of DNA-templated transcription

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.