Search Results

Overview

Uniprot ID	A0A1B0GWM1
Protein Name	CLIP-associating protein 1
Gene Name	Clasp1
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
286	MASSLGSKSSAAKEG

Function

Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle

Protein Sequence

10 MEPRMESCLA 20 QVLQKDVGKR 30 LQVGQELIDY 40 FSDKQKSADL 50 EHDQTMLDKL 60 VDGLATSWVN 70 SSNYKVVLLG 80 MDILSALVTR 90 LQDRFKAQIG 100 TVLPSLIDRL 110 GDAKDSVREQ 120 DQTLLLKIMD 130 QAANPQYVWD 140 RMLGGFKHKN 150 FRTREGICLC 160 LIATLNASGA 170 QTLTLSKIVP 180 HICNLLGDPN 190 SQVRDAAINS 200 LVEIYRHVGE 210 RVRADLSKKG 220 LPQSRLNVIF 230 TKFDEVQKSG 240 NMIQSANDKN 250 FDDEDSVDGN 260 RPSSASSSSS 270 KAPSSSRRNV 280 SMGTTRRLMA 290 SSLGSKSSAA 300 KEGAGAVDEE 310 DFIKAFDDVP 320 VVQIYSSRDL 330 EESINKIREI 340 LSDDKHDWEQ 350 RVNALKKIRS 360 LLLAGAAEYD 370 NFFQHLRLLD 380 GAFKLSAKDL 390 RSQVVREACI 400 TLGHLSSVLG 410 NKFDHGAEAI 420 MPTIFNLIPN 430 SAKIMATSGV 440 VAVRLIIRHT 450 HIPRLIPVIT 460 SNCTSKSVAV 470 RRRCFEFLDL 480 LLQEWQTHSL 490 ERHISVLAET 500 IKKGIHDADS 510 EARIEARKCY 520 WGFHSHFSRE 530 AEHLYHTLES 540 SYQKALQSHL 550 KNSDSIVSLP 560 QSDRSSSSSQ 570 ESLNRPLSAK 580 RSPTGSTASR 590 GSTVSTKSMS 600 TTGSLQRSRS 610 DIDVNAAASA 620 KSKVSSSSGS 630 TAFSSAAALP 640 PGSYASLESR 650 HMREDLEYVG 660 LDAGRIRTRR 670 QSSGSTTNVA 680 STSSDSRGRS 690 RAKVVSQSQP 700 GSRSSSPGKL 710 LGSGYGGLAG 720 GSSRGPPVTP 730 SSEKRSKIPR 740 SQGCSRETSP 750 NRIGLDRFGL 760 GQSGRIPGSV 770 SAMRVLSTST 780 DLEAAVADAL 790 LLGDARSKKK 800 PVRRRYEPYG 810 MYSDDDANSD 820 ASSVCSERSY 830 GSRNGGIPHY 840 LRQTEDVAEV 850 LNHCASSNWS 860 ERKEGLLGLQ 870 NLLKSQRTLS 880 RVELKRLCEI 890 FTRMFADPHS 900 KIADSEAECE 910 DKEGNLFPSE 920 GSCPVSWSMF 930 LETLVDFIII 940 HKDDLQDWLF 950 VLLTQLLKKM 960 GADLLGSVQA 970 KVQKALDVTR 980 DSFPFDQQFN 990 ILMRFIVDQT 1000 QTPNLKVKVA 1010 ILKYIESLAR 1020 QMDPTDFVNS 1030 SETRLAVSRI 1040 ITWTTEPKSS 1050 DVRKAAQIVL 1060 ISLFELNTPE 1070 FTMLLGALPK 1080 TFQDGATKLL 1090 HNHLKNSSNA 1100 GVGSPSNTIG 1110 RTPSRHPSSR 1120 TSPLTSPTNC 1130 SHGGLSPSML 1140 DYDTENLNSE 1150 EIYSSLRGVT 1160 EAIEKFSFRS 1170 QEDLNEPIKR 1180 DGKKDCDIVS 1190 RDGGAASPAT 1200 EGRGGSEVEG 1210 GRMALDNKTS 1220 LLNTQPPRAF 1230 PGPRAREYNP 1240 YPYSDTINTY 1250 DKTALKEAVF 1260 DDDMEQLRDV 1270 PIDHSDLVAD 1280 LLKELSNHNE 1290 RVEERKGALL 1300 ELLKITREDS 1310 LGVWEEHFKT 1320 ILLLLLETLG 1330 DKDHSIRALA 1340 LRVLREILRN 1350 QPARFKNYAE 1360 LTIMKTLEAH 1370 KDSHKEVVRA 1380 AEEAASTLAS 1390 SIHPEQCIKV 1400 LCPIIQTADY 1410 PINLAAIKMQ 1420 TKVVERITKE 1430 SLLQLLVDII 1440 PGLLQGYDNT 1450 ESSVRKASVF 1460 CLVAIYSVIG 1470 EDLKPHLAQL 1480 TGSKMKLLNL 1490 YIKRAQTTNS 1500 NSSSSSDVST HS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0000776	kinetochore
Cellular Component	GO:0005874	microtubule
Cellular Component	GO:0005819	spindle
Molecular Function	GO:0008017	microtubule binding
Biological Process	GO:0051301	cell division
Biological Process	GO:0051494	negative regulation of cytoskeleton organization
Biological Process	GO:1902904	negative regulation of supramolecular fiber organization
Biological Process	GO:0031110	regulation of microtubule polymerization or depolymerization

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.