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Overview

Uniprot IDA0A1B0GWN0
Protein NameGeneral transcription factor II-I
Gene NameGtf2i
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
341 VREFNFEKWNARITD

Function

Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation

Protein Sequence

10 MAQVAMSALP 20 AEDEESSESR 30 MVVTFLMSAL 40 ESMCKELAKS 50 KAEVACIAVY 60 ETDVFVVGTE 70 RGRAFVNTRK 80 DFQKDFVKYC 90 VEEEEKAAEM 100 HKMKCTTQAN 110 RMSVDAVEIE 120 TLRKTVEDYF 130 CFCYGKALGK 140 STVVPVPYEK 150 MLRDQSAVAV 160 QGLPEGVAFK 170 HPEHYDLATL 180 KWILENKAGI 190 SFIIKRPFLE 200 PKKHLGGRVM 210 AADADRPMLS 220 PGGSCGPIKV 230 KTEPTEDSGI 240 SLEMAAVTVK 250 EESEDPDYYQ 260 YNIQAGPSET 270 DDVDEKLPLS 280 KALQEFYFFQ 290 DSTQHVPSET 300 SEDPEVEVTI 310 EDDDYSPPTK 320 RPKSSEPPPP 330 PPVPEPTNAG 340 KRKVREFNFE 350 KWNARITDLR 360 KQVEELFERK 370 YAQAIKAKGP 380 VTIPYPLFQS 390 HVEDLYVEGL 400 PEGIPFRRPS 410 TYGIPRLERI 420 LLAKERIRFV 430 IKKHELLNST 440 REDLQLDKPA 450 SGVKEEWYAR 460 ITKLRKMVDQ 470 LFCKKFAEAL 480 GSTEAKAVPY 490 QKFEAYPNDL 500 YVEGLPENIP 510 FRSPSWYGIP 520 RLEKIIQVGN 530 RIKFVIKRPE 540 LLTHSTTEVT 550 QPRTNTPVKE 560 DWNVRITKLR 570 KQVEEIFNLK 580 FAQALGLTEA 590 VKVPYPVFES 600 NPEFLYVEGL 610 PEGIPFRSPT 620 WFGIPRLERI 630 VRGSNKIKFV 640 VKKPELVVSY 650 LPPGMASKIN 660 TKALQSPKRP 670 RSPGSNSKVP 680 EIEVTVEGPN 690 NNSPQTSTVR 700 TPTQTNGSNV 710 PFKPRGREFS 720 FEAWNAKITD 730 LKQKVENLFN 740 EKCGEALGLK 750 QAVKVPFALF 760 ESFPEDFYVE 770 GLPEGVPFRR 780 PSTFGIPRLE 790 KILRNKAKIK 800 FIIKKPEMFE 810 TAIKESTSSK 820 SPPRKTNSSP 830 SVNTTASGVE 840 DLNIIQVTIP 850 DDDNERLSKV 860 EKARQLREQV 870 NDLFSRKFGE 880 AIGMGFPVKV 890 PYRKITINPG 900 CVVVDGMPPG 910 VSFKAPSYLE 920 ISSMRRILDS 930 AEFIKFTVIS 940 HLNCLSPFVT 950 ELVDQNESEG 960 PVIQGEESAV 970 GQLTPCYPFA 980 SSVEIKETDG 990 SSQIKQEPDP TW

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003677 DNA binding
Biological Process GO:0006366 transcription by RNA polymerase II

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.