Search Results
Overview
| Uniprot ID | A0A1D5YKH2 |
|---|---|
| Protein Name | Histone H2A |
| Gene Name | LOC123122788 |
| Organism | Triticum aestivum |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 13 | GKGLLAAKTTAAKTA |
| 133 | IHKSLINKSSKE*** |
| 18 | AAKTTAAKTAEKDKG |
| 7 | *MAGKGGKGLLAAKT |
Function
Variant histones H2A are synthesized throughout the cell cycle and are very different from classical S-phase regulated H2A. May replace conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
Protein Sequence
10
MAGKGGKGLL
20
AAKTTAAKTA
30
EKDKGKKAPI
40
SRSSRAGLQF
50
PVGRIHRQLK
60
QRTQANGRVG
70
ATAAVYSAAI
80
LEYLTAEVLE
90
LAGNASKDLK
100
VKRITPRHLQ
110
LAIRGDEELD
120
TLIKGTIAGG
130
GVIPHIHKSL
INKSSKE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000786 | nucleosome |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0030527 | structural constituent of chromatin |
| Biological Process | GO:0031507 | heterochromatin formation |
Reference
[1] Zhu J, Guo W, Lan Y. Global Analysis of Lysine Lactylation of Germinated Seeds in Wheat.. Int J Mol Sci 24(22). 2023 Nov 11. PMID: 38003390.