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Overview

Uniprot ID	A0A1W2Q6F8
Protein Name	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
Gene Name	Ndufa10l1
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
122	EKFYDDPKSNDGNSY
181	YNRGFIRKQCVDHYN
285	YNKGPWLKQDDRTFH
301	LRMLVQDKREVLNYT
338	FRELPGRKYAPGYNA
52	LGDKTTKKLHEYSRV
70	DGNICSGKNKLARDI

Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Protein Sequence

10 MALRLLRLVP 20 ASASARGLAA 30 GAQRVGRIHT 40 SVHCKLRYGL 50 LASILGDKTT 60 KKLHEYSRVI 70 TVDGNICSGK 80 NKLARDIAEQ 90 LGMKHYPEAG 100 IQYSSSTTGD 110 GRPLDIEFSG 120 SCSLEKFYDD 130 PKSNDGNSYR 140 LQSWLYASRL 150 LQYSDALEHL 160 LSTGQGVVLE 170 RSIYSDFVFL 180 EAMYNRGFIR 190 KQCVDHYNEI 200 KRLTLPEYLP 210 SHAVIYIDVP 220 VSEIQSRIQK 230 KGDPHEMKVT 240 SAYLQDIEDA 250 YKKTFLPQMS 260 EICEVLMYSS 270 WEAEDSTKVV 280 EDIEYLNYNK 290 GPWLKQDDRT 300 FHNLRMLVQD 310 KREVLNYTTV 320 PVYLPEITIG 330 AHQGSRIYDS 340 FRELPGRKYA 350 PGYNADVGDK WIWLK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0045271	respiratory chain complex I
Molecular Function	GO:0008137	NADH dehydrogenase (ubiquinone) activity
Biological Process	GO:0006120	mitochondrial electron transport, NADH to ubiquinone

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.