Overview
| Uniprot ID | A0A286X7C8 |
|---|
| Protein Name | Ephrin-A1 |
|---|
| Gene Name | EFNA1 |
|---|
| Organism | Cavia porcellus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 81 |
ENYCLKLKVTVNGKI |
Function
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Involved in angiogenesis, regulating vascular endothelial cell differentiation and migration through activation of EPHA2. Acts as a ligand for EPHA3, inhibiting epithelial-to-mesenchymal transition of cardiac cells and playing a role in heart development. May also contribute to dendritic spine morphogenesis
Protein Sequence
10
MERYTLYLVD
20
YEEYAVCQPQ
30
SKDQVRWRCN
40
QPSARHGPEK
50
LSEKFQRFTP
60
FTLGKEFKEG
70
HSYYYISKPI
80
SHQENYCLKL
90
KVTVNGKITH
100
SPQAHANPQE
110
KRLQSDDPEV
120
QVLHSIGHSA
130
APRLFPLAWV
140
VLLLPLMLLQ
TQ
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0046875 |
ephrin receptor binding |
| Biological Process |
GO:0007411 |
axon guidance |
| Biological Process |
GO:0048013 |
ephrin receptor signaling pathway |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.