Search Results
Overview
| Uniprot ID | A0A286X7L6 |
|---|---|
| Protein Name | Macrophage migration inhibitory factor |
| Gene Name | MIF |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 78 | AQNRSYSKLLCGLLS |
Function
Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity
Protein Sequence
10
MPMFILNTNV
20
PRSSVPDGFL
30
SELTQQLAQA
40
TGKPAQYIAV
50
HVVPDQLMTF
60
AGSSEPCALC
70
SLHSIGKIGG
80
AQNRSYSKLL
90
CGLLSERLRI
100
SPDRVYINYY
110
DMNAANVGWN
STTFG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0042056 | chemoattractant activity |
| Molecular Function | GO:0005125 | cytokine activity |
| Molecular Function | GO:0005126 | cytokine receptor binding |
| Molecular Function | GO:0004167 | dopachrome isomerase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0050178 | phenylpyruvate tautomerase activity |
| Molecular Function | GO:0002020 | protease binding |
| Biological Process | GO:0007166 | cell surface receptor signaling pathway |
| Biological Process | GO:0006954 | inflammatory response |
| Biological Process | GO:0045087 | innate immune response |
| Biological Process | GO:2000773 | negative regulation of cellular senescence |
| Biological Process | GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:1902166 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
| Biological Process | GO:0010760 | negative regulation of macrophage chemotaxis |
| Biological Process | GO:0002906 | negative regulation of mature B cell apoptotic process |
| Biological Process | GO:0033033 | negative regulation of myeloid cell apoptotic process |
| Biological Process | GO:0051248 | negative regulation of protein metabolic process |
| Biological Process | GO:0090238 | positive regulation of arachidonate secretion |
| Biological Process | GO:0030890 | positive regulation of B cell proliferation |
| Biological Process | GO:0141163 | positive regulation of cAMP/PKA signal transduction |
| Biological Process | GO:2000343 | positive regulation of chemokine (C-X-C motif) ligand 2 production |
| Biological Process | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:0048146 | positive regulation of fibroblast proliferation |
| Biological Process | GO:0031666 | positive regulation of lipopolysaccharide-mediated signaling pathway |
| Biological Process | GO:0061081 | positive regulation of myeloid leukocyte cytokine production involved in immune response |
| Biological Process | GO:0042327 | positive regulation of phosphorylation |
| Biological Process | GO:0061078 | positive regulation of prostaglandin secretion involved in immune response |
| Biological Process | GO:0032760 | positive regulation of tumor necrosis factor production |
| Biological Process | GO:0001516 | prostaglandin biosynthetic process |
| Biological Process | GO:0070207 | protein homotrimerization |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.