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Overview

Uniprot ID	A0A286X968
Protein Name	Histone deacetylase
Gene Name	HDAC5
Organism	Cavia porcellus

Kla Sites from experimental identification

Position	Flanking peptide
433	TSMRTVGKLPQHRPL

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events

Protein Sequence

10 MNSPAKSDGA 20 PGREPSLEIL 30 PRTSLHSIPV 40 AVEVKPALPG 50 TMPSTMGPGP 60 VDPTDPVMRE 70 RQLQQELAAL 80 KQQQQLQKQL 90 LFAEFQKQHA 100 HLTRQHEAQL 110 QKHLQVGVGW 120 PGPVLPCPQH 130 SVAPPAGAIA 140 STEVKLRLQE 150 FLLSKSKEPT 160 PGGLNHSLPQ 170 HPKCWGAHHA 180 SLDQSSPPQS 190 GPPGTPPSYK 200 LPLLGPYDSR 210 DDFPLRKTAS 220 EPNLKVRSRL 230 KQKVAERRSS 240 PLLRRKDGTV 250 ISTFKKRAVE 260 ITGSGGPGNG 270 APGSGPSSPN 280 SSHSTIAENG 290 FTGSVPNIPT 300 EMLPQHRAPT 310 LDSSPNQFNL 320 YSSPSLPNIS 330 LGLQPTVTVT 340 NSHLTASAKL 350 TTQQEAERQA 360 LQSLQPGGSL 370 TGKFLSTSSI 380 PGCLLGVALE 390 GDSGSHGHAS 400 LLQHVLLLEQ 410 ARQQSTLIAV 420 PLHGQSPLVT 430 GERMATSMRT 440 VGKLPQHRPL 450 SRTQSSPLPQ 460 SPQALQQLVT 470 QQQFLEKQKQ 480 QQLQLGKILT 490 KTGELPRPPT 500 THPEETEEEL 510 TEQQEALLVE 520 EALTMPREGS 530 TESESTQEDL 540 EEDDEDLEDE 550 EDCYVQVQDP 560 AGNSGSEEGP 570 DLEEPSTGYK 580 KLFTDAPQLP 590 PLRVYQAPLS 600 LATVPHQALG 610 RTQSSPAAPG 620 GTRSPPDLPT 630 KFLFTTGPIS 640 QKMYAVLPCG 650 GIGVSCLYCP 660 FQALTGRHRN 670 GFAIIRPPGH 680 HAEESTAMGF 690 CFFNSVAITA 700 KLLQQKLSVG 710 RVLIVDWDIH 720 HGNGTQQAFY 730 TDPSVLYISL 740 HRYDNGNFFP 750 GSGAPEEVGG 760 GPGVGYNVNV 770 AWTGGVDPPI 780 GDVEYLAAFR 790 TVVMPIAHEF 800 APDVVLVSAG 810 FDAVEGHLSP 820 LGGYSVTARC 830 FGHLTRQLMT 840 LAGGRVVLAL 850 EGGHDLTAIC 860 DASEACVSAL 870 LSVELQPLDE 880 AILQQKPNIN 890 AVATLEKVIE 900 IQGKHWSCLQ 910 RFAAGLGRSL 920 REAQASEAEE 930 AETVSAMALL 940 SVGAEQAQAS 950 TQEHSPRPVE EPMEQEPAL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0141221	histone deacetylase activity, hydrolytic mechanism
Molecular Function	GO:0046872	metal ion binding
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.