Search Results

Overview

Uniprot IDA0A286X990
Protein NameSerine/arginine repetitive matrix protein 1
Gene NameSRRM1
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
132 QRQIEQEKLASMKKQ
29 KKLLKQLKFAECLEK
449 SPAPKPRKVELSESE

Function

Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates

Protein Sequence

10 MDAGFFRGTS 20 AEQDNRFSNK 30 QKKLLKQLKF 40 AECLEKKVDM 50 SKVNLEVIKP 60 WITKRVTEIL 70 GFEDDVVIEF 80 IFNQLEVKNP 90 DSKMMQINLT 100 GFLNGKNARE 110 LWENFENIAG 120 IPTAFLELKK 130 EEIKQRQIEQ 140 EKLASMKKQD 150 EDKDKRDKEE 160 KESSREKRER 170 SRSPRRRKSR 180 SPSPRRRSSP 190 VRRERKRSHS 200 RSPRHRTKSR 210 SPTPAPEKKE 220 KTPELPEPSV 230 KVKEPSVQEA 240 TSTSDILKVP 250 KPEPMPEPKE 260 PSPEKNSKKE 270 KEKTRPRSRS 280 RSKSRSRTRS 290 RSPSHTRPRR 300 RHRSRSRSYS 310 PRRRPSPRRR 320 PSPRRRTPPR 330 RMPPPPRHRR 340 SRSPVRRRRR 350 SSASLSGSSS 360 SSSSSRSRSP 370 PKKPPKRTSS 380 PPRKTRRLSP 390 SASPPRRRHR 400 PSPPATPPPK 410 TRHSPTPQQS 420 NRTRKSRVSV 430 SPGRTSGKVT 440 KHKGTEKRES 450 PSPAPKPRKV 460 ELSESEEDKG 470 GKMAAADSVQ 480 QRRQYRRQNQ 490 QSSSDSGSSS 500 SSEDERPKRS 510 HVKNGEVGRR 520 RRHSPSRSAS 530 PSPRKRQKET 540 SPRGRRRRSP 550 SPPPARRRRS 560 PSPAPPPRRR 570 RSPTPPPRRR 580 TPSPPPRRRS 590 PSPRRYSPPI 600 QRRYSPSPPP 610 KRRTASPPPP 620 PKRRASPSPP 630 PKRRVSPSPP 640 PKQRSSPATK 650 RRSPSLSSKH 660 RKGSSPSRAP 670 RETRSPQPNK 680 RHSPSPRPRV 690 PQTSSPPPVR 700 RGTSASPQRR 710 QSPSPSTRPI 720 RRVSRTPELK 730 KTKKAASPSP 740 QSVRRVSSSR 750 SVSGSPEPAK 760 KPPAPPSPVQ 770 SQSPSTNWSP 780 AVPVKKAKSP 790 TPSPSPARNS 800 DQEGGGKKKK 810 KKKDKKHKKD 820 KKHKKHKKHK 830 KEKAVAAAAV 840 APTAPAAVAP 850 TTTTSAQEEP 860 EAAPEPKKET 870 ESEAEDNLDD 880 LEKHLREKAL 890 RSMRKAQVSP QS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005681 spliceosomal complex
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006397 mRNA processing
Biological Process GO:0048024 regulation of mRNA splicing, via spliceosome
Biological Process GO:0008380 RNA splicing

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.