Search Results
Overview
| Uniprot ID | A0A286XAD8 |
|---|---|
| Protein Name | Splicing factor 1 |
| Gene Name | SF1 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 295 | DPQSAQDKARMDKEY |
Function
Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor
Protein Sequence
10
FPSKKRKRSR
20
WNQDTMEQKT
30
VIPGMPTVIP
40
PGLTREQERA
50
YIVQLQIEDL
60
TRKLRTGDLG
70
IPPNPEDRSP
80
SPEPIYNSEG
90
KRLNTREFRT
100
RKKLEEERHN
110
LITEMVALNP
120
DFKPPADYKP
130
PATRVSDKVM
140
IPQDEYPEIN
150
FVGLLIGPRG
160
NTLKNIEKEC
170
NAKIMIRGKG
180
SVKEGKVGRK
190
DGQMLPGEDE
200
PLHALVTANT
210
MENVKKAVEQ
220
IRNILKQGIE
230
TPEDQNDLRK
240
MQLRELARLN
250
GTLREDDNRI
260
LRPWQSSETR
270
SITNTTVCTK
280
CGGAGHIASD
290
CKFQRPGDPQ
300
SAQDKARMDK
310
EYLSLMAELG
320
EAPVPASVGS
330
TSGPTATPLA
340
SAPRPAAPAN
350
NPPPPSLMST
360
TQSRPPWMNS
370
GPSESRPYHG
380
MHGGGPGGPG
390
GGPHSFPHPL
400
PSLTGGHGGH
410
PMQHNPNGPP
420
PPWMQPPPPP
430
MNQGPHPPGH
440
HGPPPMDQYL
450
GSTPVGSGVY
460
RLHQGKGMMP
470
PPPMGMMPPP
480
PPPPSGQPPP
490
PPSGPLPPWQ
500
QQQQQPPPPP
510
PPSSSMASST
520
PLPWQQRSLP
530
AAAMARAMRV
RTFRAHW
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005681 | spliceosomal complex |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:0045131 | pre-mRNA branch point binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0000398 | mRNA splicing, via spliceosome |
| Biological Process | GO:0048024 | regulation of mRNA splicing, via spliceosome |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.